Figure 4. Optical coherence tomography (OCT) scans demonstrate protection of ONL by pyruvate and nicotinamide against LD. A: Representative ONL images were taken from OCT in control, 7 days after 4 h light damage in non-dark conditions (4 h LD (light)), 4 h LD (light) + P, 4 h LD (light) + N, and 4 h LD (light) + L, where P, N, and L refer to 500 mg/kg i.p. injection before LD and 3x/week of pyruvate, nicotinamide, or lactate, respectively. Bar represents 50 microns. B: The mean thickness in central superior and central inferior hemispheres (arrow or bar in A) of the retina in microns after these exposures is presented ± SEM (n=6). * indicates difference from control, # indicates difference from light damage, and $ indicates difference between dark maintained and non-dark maintained retinas at p<0.05 by one-way ANOVA and a Bonferroni test.