Figure 5 of Varma, Mol Vis 2010; 16:2626-2633.


Figure 5. Induction of apoptosis. Prevention by caffeine. The pictures represent the sections of the lens stained with DAPI (A-D) and F-UTP (E-H) Sections A and E represent normal lenses. Sections B and F represent the lenses from normal rats treated with caffeine eye drops. Sections C and G represent lenses from galactose group treated with placebo. Sections D and H represent caffeine treated group. Photographs C and G indicate defective transformation of the epithelial cells into fiber cells, indicated by retention of nuclei and/or apoptosis. Sections D and H prove that caffeine inhibits such apoptotic process.