Figure 1. Sequence chromatograms of mutations in retinopathy of prematurity. Left: The chromatogram of ND gene exon 1. It shows the antisense sequence between nucleotide 231 and 245. Retinopathy of prematurity (ROP) #10 shows a heterozygous mutation at 237 T->C. Right: The chromatogram of LRP5 gene exon 1. C, D indicate a sense sequence including CTG repeat regions. The text below each normal chromatogram represents a mutated sequence. ROP #15 shows a heterozygous 3-bp insertion (CTG) that introduced another leucine insertion in the polyleucine region. A, C indicate a sequence of an unaffected individual. B indicates a sequence of ROP #10. D indicates sequence of ROP #15.