Figure 7. Differential effects of
Nε-(3-formyl-3,4-dehydropiperidino)lysine (FDP-lysine) on heme
oxygenase 1 (HO-1), glial fibrillary acidic protein (GFAP), and Kir4.1
protein levels. A-F: Representative western blots and
corresponding quantification for HO-1, GFAP, and Kir4.1 protein levels
in control and FDP-lysine human serum albumin (HSA)-treated human
Muller (MIO-M1) cells. Incubation with FDP-lysine-HSA evoked a
concentration-dependent increase in HO-1, no change in total GFAP
levels, and a decrease in Kir4.1 protein expression at high treatment
concentrations (≥0.4 mg/ml).