Figure 4. Figure 4. Representative bleb photographs after surgery. A-C: siRNA group, D-F: MMC group, G-I: PBS group, on day 3, day 21, and day 49, respectively. Treatment with IKKβ-siRNA was associated with an elevated, diffuse, fleshy-looking bleb compared with the flat, scarred bleb in the PBS group (day21 and day 49). MMC treated eyes were associated with typical avascular cystic blebs surrounded by local conjunctival hyperemia while IKKβ-siRNA resulted in a relatively less-elevated bleb and a normal-appearing conjunctiva.