Table 5 of Seddon, Mol Vis 2010; 16:2412-2424. Table 5 of Seddon, Mol Vis 2010; 16:2412-2424.
Table 5. Assessment of effect of interactions between hepatic lipase (LIPC) genotype (rs10468017) and other genes on risk of age-related macular degeneration.
| LIPC genotype | |||
|---|---|---|---|
| Number of cases | CC | CT & TT | |
| Combined Advanced AMD | 293 | 252 | |
| Geographic Atrophy | 82 | 57 | |
| Neovascular AMD | 211 | 195 | |
| Number of controls | 128 | 147 | |
| OR (CI) * | OR (CI) * | ||
| CFH: rs1061170 (Y402H) | |||
| TT | 1.0 | 0.5 (0.3 - 0.9) | |
| CT | 1.7 (1.0 - 2.9) | 1.9 (1.1 - 3.3) | |
| CC | 5.6 (2.8 - 11.0) | 5.3 (2.7 - 10.3) | |
| p (interaction) | 0.12 (CT-TT versus CC) | ||
| CFH: rs1410996 | |||
| TT | 1.0 | 0.6 (0.2 - 2.0) | |
| CT | 2.8 (1.1 - 6.7) | 1.6 (0.7 - 4.0) | |
| CC | 7.8 (3.2 - 19.0) | 9.9 (4.0 - 24.5) | |
| p (interaction) | 0.05 (CT -TT vs CC) | ||
| ARMS2/HTRA1: rs10490924 | |||
| GG | 1.0 | 0.9 (0.6 - 1.5) | |
| GT | 3.9 (2.4 - 6.3) | 2.6 (1.6 - 4.1) | |
| TT | 21.2 (6.3 - 71.9) | 12.8 (4.3 - 37.9) | |
| p (interaction) | 0.32(CT-TT versus CC) | ||
| CFB: rs641153 (R32Q) | |||
| CC | 1.0 | 0.9 (0.6 - 1.3) | |
| CT/TT | 0.3 (0.2 - 0.6) | 0.1 (0.1 - 0.3) | |
| p (interaction) | 0.14 (CT-TT versus CC) | ||
| C2: rs9332739 (E318D) | 1.0 | ||
| GG | 0.4 (0.1 - 1.4) | 0.9 (0.6 - 1.2) | |
| CG/CC | 0.2 (0.1 - 0.5) | ||
| P (Interaction) | 0.13 (CT-TT versus CC) | ||
| C3: rs2230199 (R102H) | 1.0 (0.6 - 1.4) | ||
| CC | 1.0 | ||
| CG | 1.8 (1.1 - 2.8) | 1.4 (0.9 - 2.2) | |
| GG | 8.8 (2.0 - 39.4) | 1.5 (0.6 - 3.8) | |
| p (interaction) | 0.10 (CT-TT versus CC) | ||
| CFI: rs10033900 | |||
| CC | 1.0 | 0.7 (0.4 - 1.3) | |
| CT | 1.5 (0.9 - 2.5) | 0.9 (0.5 - 1.5) | |
| TT | 1.1 (0.6 - 2.0) | 2.1 (1.1 - 4.1) | |
| p (interaction) | 0.04 (CT-TT versus CC) |