Table 4 of Seddon, Mol Vis 2010; 16:2412-2424. Table 4 of Seddon, Mol Vis 2010; 16:2412-2424.
Table 4. Assessment of effect of interactions between hepatic lipase-C (LIPC) genotype and lifestyle factors on risk of age-related macular degeneration (AMD).
| LIPC genotype | P (Trend) for Number of T alleles | ||||
|---|---|---|---|---|---|
| CC | CT | TT | |||
| Number of cases | |||||
| Combined Advanced AMD | 293 | 224 | 28 | ||
| Geographic Atrophy | 82 | 50 | 7 | ||
| Neovascular AMD | 211 | 174 | 21 | ||
| Number of controls | 128 | 121 | 26 | ||
| OR (CI)* | OR (CI)* | OR (CI)* | |||
| BMI | Combined Advanced AMD | ||||
| <25 | 1.0 | 1.1 (0.6 - 2.0) | 0.6 (0.2 - 1.8) | ||
| 25+ | 1.7 (1.0 - 2.8) | 1.4 (0.8 - 2.3) | 0.7 (0.3 - 1.6) | ||
| P (Interaction) | 0.40 (CT vs. CC) | 0.59 (TT vs. CC) | 0.40 | ||
| Smoking | Combined Advanced AMD | ||||
| Never | 1.0 | 1.1 (0.7 - 1.8) | 0.6 (0.2 - 1.3) | ||
| Ever | 2.1 (1.4 - 3.3) | 1.6 (1.0 - 2.5) | 0.7 (0.3 - 1.8) | ||
| P (Interaction) | 0.27 (CT vs CC) | 0.43 (TT vs. CC) | 0.30 | ||
| Lutein: | Combined Advanced AMD | ||||
| calorie adjusted, | ≤mean† | 1.0 | 0.8 (0.5 - 1.3) | 0.7 (0.3 - 1.7) | |
| sex specific | > mean† | 0.7 (0.4 - 1.1) | 0.7 (0.4 - 1.1) | 0.2 (0.1 - 0.5) | |
| P (Interaction) | 0.62 (CT vs. CC) | 0.11 (TT vs. CC) | 0.83 | ||