Molecular Vision: Seddon, Mol Vis 2010; 16:2412-2424. Table 3

Table 3. Multivariate analyses of associations between advanced age-related macular degeneration (AMD), hepatic lipase-C (LIPC) genotypes, and demographic, genetic, and behavioral risk factors.

	Combined advanced AMD		Geographic atrophy		Neovascular AMD
	545/275		139/275		406/275
Number of cases/controls	OR (CI)	p value	OR (CI)	p value	OR (CI)	p value
LIPC genotype
Multivariate model 1
CC	1		1		1
CT	0.9 (0.7-1.2)	0.529	0.7 (0.4-1.1)	0.143	1.0 (0.7-1.4)	0.87
TT	0.5 (0.2-0.9)	0.014	0.5 (0.2-1.3)	0.152	0.4 (0.2-0.9)	0.02
Number of T alleles (p - trend)		0.047		0.062		0.105
Multivariate Model 2
CC	1		1		1
CT	1.0 (0.6 - 1.4)	0.846	0.9 (0.5-1.6)	0.805	1.0 (0.6-1.5)	0.97
TT	0.5 (0.2 - 1.1)	0.077	0.7 (0.2-2.2)	0.555	0.4 (0.2-1.1)	0.066
Number of T alleles (p - trend)		0.21		0.587		0.22
Age
Multivariate Model 1
<70	1		1		1
≥70	3.2 (2.3 - 4.4)	<0.0001	2.9 (1.8 - 4.6)	<0.0001	3.3 (2.3 - 4.7)	<0.0001
Multivariate Model 2
<70	1		1		1
≥70	3.3 (2.2 - 4.9)	<0.0001	3.1 (1.8 - 5.4)	<0.0001	3.9 (2.5 - 6.0)	<0.0001
Gender
Multivariate Model 1
Male	1		1		1
Female	0.8 (0.6 - 1.1)	0.125	1.2 (0.8 - 1.9)	0.437	0.7 (0.5 - 1.0)	0.026
Multivariate Model 2
Male	1		1		1
Female	0.9 (0.6 - 1.3)	0.42	1.2 (0.7 - 2.1)	0.442	0.7 (0.5 - 1.1)	0.13
Education
Multivariate Model 1
≤HS	1		1		1
>HS	0.4 (0.2 - 0.8)	0.007	0.4 (0.2 - 1.0)	0.061	0.4 (0.2 - 0.7)	0.005
Multivariate Model 2
≤HS	1		1		1
>HS	0.5 (0.2 - 1.1)	0.079	0.4 (0.1 - 1.1)	0.074	0.6 (0.2 - 1.4)	0.2
Smoking
Multivariate Model 1
Ever	1		1		1
Past	1.5 (1.1 - 2.2)	0.01	1.8 (1.1 - 2.9)	0.016	1.5 (1.1 - 2.1)	0.024
Current	3.9 (2.0 - 7.7)	<0.0001	4.0 (1.6 - 9.6)	0.002	3.9 (1.9 - 7.9)	0.0002
Multivariate Model 2
Never	1		1		1
Past	2.0 (1.3 - 3.0)	0.001	1.8 (1.0 - 3.1)	0.054	2.1 (1.3 - 3.3)	0.001
Current	4.5 (2.1 - 10.1)	0.0002	4.3 (1.4 - 13.0)	0.009	4.8 (2.1 - 11.2)	0.0002
BMI
Multivariate Model 1
<25	1		1		1
25 - 29.9	1.3 (0.9 - 1.9)	0.15	1.1 (0.6 - 1.8)	0.85	1.4 (1.0 - 2.1)	0.085
>=30	2.0 (1.3 - 3.1)	0.002	1.8 (1.0 - 3.2)	0.057	2.1 (1.3 - 3.4)	0.002
(p-trend)		0.002		0.064		0.002
Multivariate Model 2
<25	1		1		1
25 - 29.9	1.2 (0.7 - 1.9)	0.50	0.9 (0.5 - 1.7)	0.72	1.4 (0.8 - 2.3)	0.20
>=30	2.0 (1.2 - 3.3)	0.01	1.7 (0.8 - 3.5)	0.15	2.3 (1.3 - 4.0)	0.005
(p-trend)		0.01		0.81		0.005
Calorie adjusted, sex-specific Lutein (tertiles)
Multivariate Model 1
1st tertile	1		1		1
2nd tertile	0.7 (0.5 - 1.1)	0.13	0.7 (0.4 - 1.3)	0.25	0.8 (0.5 - 1.2)	0.27
3rd tertile	0.6 (0.4 - 1.0)	0.029	0.6 (0.4 - 1.1)	0.11	0.7 (0.4 - 1.0)	0.056
(p - trend)		0.031		0.11		0.057
Multivariate Model 2
1st tertile	1		1		1
2nd tertile	0.8 (0.5 - 1.3)	0.46	0.7 (0.4 - 1.3)	0.282	0.9 (0.6 - 1.6)	0.79
3rd tertile	0.7 (0.4 - 1.1)	0.099	0.6 (0.3 - 1.1)	0.077	0.8 (0.5 - 1.3)	0.30
(p - trend)		0.097		0.078		0.29

OR=Odds Ratio, CI=95% Confidence Interval, Multivariate 1=Model Adjusted for age (50 - 69, 70 −95), gender, education (≤ high school versus > high school), smoking (never, past, current), BMI (<25, 25 - 29.9, ≥30), LIPC (CC, CT, TT), antioxidant treatment (supplement containing antioxidants versus supplement containing no antioxidants), calorie adjusted lutein (tertile ranges micrograms: females-1=170.7 - 1096.6, 2=1096.7 - 1685.8, 3=1685.9 - 7259.0; males-1=151.4 - 1107.7, 2=1107.8 - 1669.0, 3=1669.1 - 11614.0) Multivariate 2=Model Adjusted for all variables in Multivariate 1 plus CFH Y402H (TT, CT, CC), CFHrs1410966 (TT, CT, CC), C2 (GG, CG/CC), CFB (CC,CT/TT), ARMS2/HTRA1 (GG, GT, TT), C3 (CC, CG, GG), CFI (CC, CT, TT).