Table 1 of Seddon, Mol Vis 2010; 16:2412-2424. Table 1 of Seddon, Mol Vis 2010; 16:2412-2424.
Table 1. Distribution of demographic and behavioral risk factors for advanced age-related macular degeneration and controls according to hepatic lipase-C (LIPC) genotypes.
| Controls | Geographic atrophy | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CC | CT | TT | CC | CT | TT | |||||||||
| LIPC: rs10468017 Genotype | N | % | N | % | N | % | p value* | N | % | N | % | N | % | p value* |
| Baseline age | ||||||||||||||
| 50-69 | 89 | (70) | 92 | (76) | 21 | (81) | 38 | (46) | 28 | (56) | 4 | (57) | ||
| 70-95 | 39 | (30) | 29 | (24) | 5 | (19) | 0.30 | 44 | (54) | 22 | (44) | 3 | (43) | 0.57 |
| Gender | ||||||||||||||
| Male | 58 | (45) | 57 | (47) | 10 | (38) | 44 | (54) | 24 | (48) | 3 | (43) | ||
| Female | 70 | (55) | 64 | (53) | 16 | (62) | 0.49 | 38 | (46) | 26 | (52) | 4 | (57) | 0.58 |
| Education | ||||||||||||||
| High School or Less | 7 | (5) | 4 | (3) | 1 | (4) | 7 | (9) | 6 | (12) | 0 | 0.0 | ||
| College or more | 121 | (95) | 117 | (97) | 25 | (96) | 0.80 | 75 | (91) | 44 | (88) | 7 | 100.0 | 0.47 |
| Smoking | ||||||||||||||
| Never | 67 | (52) | 56 | (46) | 15 | (58) | 30 | (37) | 16 | (32) | 3 | (43) | ||
| Former | 58 | (45) | 57 | (47) | 10 | (38) | 0.50 | 42 | (51) | 31 | (62) | 3 | (43) | 0.71 |
| Current | 3 | (2) | 8 | (7) | 1 | (4) | 0.99 | 10 | (12) | 3 | (6) | 1 | (14) | 1.00 |
| BMI | ||||||||||||||
| <25.0 | 39 | (30) | 40 | (33) | 9 | (35) | 23 | (28) | 16 | (32) | 3 | (43) | ||
| 25.0-29.9 | 55 | (43) | 59 | (49) | 13 | (50) | 0.98 | 35 | (43) | 20 | (40) | 1 | (14) | 0.17 |
| ≥ 30.0 | 34 | (27) | 22 | (18) | 4 | (15) | 0.35 | 24 | (29) | 14 | (28) | 3 | (43) | 0.97 |
| P for Trend | 0.40 | 0.97 | ||||||||||||
| Supplements | ||||||||||||||
| No Antioxidants | 69 | (54) | 66 | (55) | 17 | (65) | 44 | (54) | 30 | (60) | 4 | (57) | ||
| Antioxidants | 59 | (46) | 55 | (45) | 9 | (35) | 0.28 | 38 | (46) | 20 | (40) | 3 | (43) | 0.84 |
| Lutein: Calorie Adjusted, Sex specific (mean µg) | ||||||||||||||
| Males | 1543.1 | 1703.1 | 1520.6 | 0.55 | 1329.5 | 1549.6 | 1100.7 | 0.67 | ||||||
| Females | 1468.0 | 1374.1 | 1607.8 | 0.91 | 1221.2 | 1361.6 | 1193.4 | 0.65 | ||||||
| Neovascular disease | Combined advanced AMD | |||||||||||||
| CC | CT | TT | CC | CT | TT | |||||||||
| LIPC: rs10468017 Genotype | N | % | N | % | N | % | p value* | N | % | N | % | N | % | p value* |
| Baseline Age | ||||||||||||||
| 50-69 | 102 | (48) | 89 | (51) | 4 | (19) | 140 | (48) | 117 | (52) | 8 | (29) | ||
| 70-95 | 109 | (52) | 85 | (49) | 17 | (81) | 0.01 | 153 | (52) | 107 | (48) | 20 | (71) | 0.05 |
| Gender | ||||||||||||||
| Male | 88 | (42) | 64 | (37) | 6 | (29) | 132 | (45) | 88 | (39) | 9 | (32) | ||
| Female | 123 | (58) | 110 | (63) | 15 | (71) | 0.24 | 161 | (55) | 136 | (61) | 19 | (68) | 0.18 |
| Education | ||||||||||||||
| High School or Less | 32 | (15) | 11 | (6) | 5 | (24) | 39 | (13) | 17 | (8) | 5 | (18) | ||
| College or more | 179 | (85) | 163 | (94) | 16 | (76) | 0.24 | 254 | (87) | 207 | (92) | 23 | (82) | 0.48 |
| Smoking | ||||||||||||||
| Never | 78 | (37) | 70 | (40) | 11 | (52) | 108 | (37) | 86 | (38) | 14 | (50) | ||
| Former | 108 | (51) | 82 | (47) | 8 | (38) | 0.18 | 150 | (51) | 113 | (50) | 11 | (39) | 0.17 |
| Current | 25 | (12) | 22 | (13) | 2 | (10) | 0.48 | 35 | (12) | 25 | (11) | 3 | (11) | 0.53 |
| BMI | ||||||||||||||
| <25.0 | 45 | (21) | 51 | (29) | 4 | (19) | 68 | (23) | 67 | (30) | 7 | (25) | ||
| 25.0-29.9 | 100 | (47) | 74 | (43) | 10 | (48) | 0.86 | 135 | (46) | 94 | (42) | 11 | (39) | 0.63 |
| ≥ 30.0 | 66 | (31) | 49 | (28) | 7 | (33) | 0.79 | 90 | (31) | 63 | (28) | 10 | (36) | 0.87 |
| p for Trend | 0.80 | 0.84 | ||||||||||||
| Supplements | ||||||||||||||
| No Antioxidants | 109 | (52) | 84 | (48) | 8 | (38) | 153 | (52) | 114 | (51) | 12 | (43) | ||
| Antioxidants | 102 | (48) | 90 | (52) | 13 | (62) | 0.24 | 140 | (48) | 110 | (49) | 16 | (57) | 0.34 |
| Lutein: Calorie Adjusted, Sex specific (mean µg) | ||||||||||||||
| Males | 1430.4 | 1651.6 | 1295.3 | 0.28 | 1395.9 | 1623.1 | 1226.9 | 0.25 | ||||||
| Females | 1254.8 | 1203.0 | 1315.6 | 0.86 | 1246.8 | 1231.8 | 1288.9 | 0.98 | ||||||