Table 1 of Böhringer, Mol Vis 2010; 16:2362-2367.

Table 1. Two examples for calculating the tolerogenicity factor from the donor‘s and recipient‘s HLA-phenotypes.


Examples		 HLA
class
Donor
Recipient		 Eplet
mismatches		 Tolerance
factor
Example 1 (tolerogenic situation)
  HLA-A/B A*0301 A*2402 B*3501 A*0301 A*2402 B*4402 B*5601 4 72–42=33
 
HLA-DR DRB1*1101 DRB1*1501 DRB1*1101 DRB1*0401 7
Example 2 (immunogenic situation)
  HLA-A/B A*0201 A*0301 B*4402 A*0201 A*2902 B*0702 B*4402 4 212–42=425
 
HLA-DR DRB1*0401 DRB1*1201 DRB1*0101 DRB1*1101 21

Mismatched donor alleles are in boldface. The count of eplet mismatches was determined by HLAMachmaker. Eplet mismatches for HLA-A/B function as factor for conventional histocompatibility. The tolerance factor is calculated from the amount of mismatches from HLA-A/B and HLA-DR according to the equation shown in the Methods.

Böhringer, Mol Vis 2010; 16:2362-2367. http://www.molvis.org/molvis/v16/a253

©2010 Molecular Vision http://www.molvis.org/molvis/

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