Figure 2. Intrastromal injection of NP2-targeting amiRNA inhibits suture-induced corneal lymphangiogenesis but not hemangiogenesis. A-C: Representative images showing that corneal suture injury induced a robust neovascular response seven days after injury. D-L: Representative segments of corneal whole-mounts (blood vessels in green: CD31/FITC; lymphatic vessels in red: LYVE-1/Cy3) in eyes treated with NP2-amiR (F, I, L, n=9 mice) or neg-amiR (E, H, K, n=7 mice) compared with the saline control eyes (D, G, J, n=8 mice). Arrows: limbus. Original magnification, 100×. M: Quantification of immunohistochemical staining in the area of CD31-possitive blood vessels and LYVE-1-possitive lymphatic vessels. Bars, SEM. The asterisk indicates a p<0.05 versus saline control. The vasculized area of control group was defined as 100%.