Figure 5. Comparison of wild-type and mutant AQP0 structural models by SWISS-MODEL. A: The wild-type AQP0 structural model contains six transmembrane α-helical domains with a short 9 amino acid NH₂-terminus and a longer 39 amino acid COOH-terminus extending into the cytoplasm. B: The mutant AQP0 structural model shows the absence of the last α-helical domain as well as the complete COOH-terminus.