Molecular Vision: McKay, Mol Vis 2010; 16:194-199. Table 3

Table 3. Estimates of AMD risk from a logistic regression model with terms for smoking, CFH haplotype [6], genotype at ARMS2 A69S (rs10490924) and the risk associated with the CC2/CFB region [8].

Regression term	OR	95% C.I.		Significance
Ex-smoker versus never smoker	2.34	1.59	3.5	<0.001
Current smoker versus never smoker	5.04	2.96	8.58	<0.001
Number of CFH haplotype 1	3.66	2.24	5.98	<0.001
Number of CFH haplotype 2	4.5	2.85	7.09	<0.001
Number of CFH haplotype 3	2.95	1.8	4.81	<0.001
Number of CFH haplotype 4	1.68	1.01	2.81	0.047
ARMS2 A69S heterozygous	3.64	2.47	5.36	<0.001
ARMS2 A69S homozygous	25.3	13.6	47.2	<0.001
rs641153  (CFB)	0.3	0.18	0.5	<0.001
rs9332739  (CC2)	0.55	0.3	1.01	0.056
rs2230199  (C3)	1.45	1.1	1.91	0.009
Age/year	1.1	1.08	1.13	<0.001

Risks associated with smoking are relative to never smokers. CFH haplotypes (1–4; haplotypes 1 and 2 increase risk and are in complete LD with the C risk allele at Y402H while 3 and 4 are non-risk and in complete LD with the T allele at Y402H) are measured against haplotype 5 (the most protective haplotype, which is in complete LD with the deletion at CFHR-3) [6]. ARMS2 is measured on the heterozygosity or homozygosity of the A69S risk allele (rs10490924). rs641153 (CFB), rs9332739 (CC2) and rs2230199 (C3) were coded as 0, 1 or 2 depending on the number of copies of the minor allele present.