Figure 2. Diabetes induces defects in retinal vascular autoregulation in both humans and mice. A: The retinal arterial diameter response to stimulation with flickering light in age- and sex-matched controls and patients with type 1 diabetes mellitus. B: Plot of superior hemiretinal ΔPO₂ during carbogen breathing indiabetic mice and sex-matched nondiabetic controls. * Significant difference (p<0.05). Figure A has been modified from Investigative Ophthalmology and Visual Science 50:4029–32, 2009, and Figure B from Diabetes (Copyright 2010 American Diabetes Association From Diabetes®, Vol. 53, 2004; 173–178. Modified with permission from The American Diabetes Association).