Table 4 of Jiang, Mol Vis 2010; 16:2092-2108. Table 4 of Jiang, Mol Vis 2010; 16:2092-2108.
Table 4. Selected genes detected at increased levels in the glaucomatous canine retina.
| Probe Set ID | Gene | Annotation | Glau_avg | Cont_avg | Fold change | q-value (%) |
|---|---|---|---|---|---|---|
| Complement components | ||||||
| *Cfa.1379.1.S1_at | C1QA* | “complement component 1, q subcomponent, A chain” | 11.8 | 9.6 | 4.3 | 0 |
| Cfa.16857.1.S1_at | C1QB | “complement component 1, q subcomponent, B chain” | 10.9 | 8.1 | 5.5 | 0 |
| *Cfa.10921.1.S1_at | C1QC* | “complement component 1, q subcomponent, C chain” | 11.4 | 8.0 | 9.3 | 0 |
| *Cfa.21168.1.S1_s_at | C1R* | “complement component 1, r subcomponent” | 8.0 | 6.3 | 2.9 | 0 |
| *Cfa.10821.1.A1_s_at | C1S* | “complement component 1, s subcomponent” | 12.3 | 10.5 | 3.5 | 0 |
| *Cfa.12240.1.A1_at | C3* | complement component 3 | 13.7 | 9.1 | 21.8 | 0 |
| CfaAff × 0.21480.1.S1_at | C3AR1* | complement component 3a receptor 1 | 6.9 | 5.6 | 2.0 | 0 |
| *Cfa.14267.1.S1_at | CFB* | complement factor B | 11.0 | 9.3 | 2.9 | 0 |
| *Cfa.14495.2.S1_at | CFI* | complement factor I | 10.6 | 8.8 | 3.2 | 0 |
| *Cfa.21548.1.S1_s_at | LOC481722* | similar to Complement C4 precursor | 8.6 | 6.3 | 4.7 | 0 |
| *Cfa.3117.1.S1_at | SERPING1* | “serpin peptidase inhibitor, clade G (C1 inhibitor)” | 12.5 | 10.3 | 4.2 | 0 |
| CfaAff × 0.24815.1.S1_at | TLR1 | toll-like receptor 1 | 7.7 | 6.5 | 2.5 | 0.181332902 |
| CfaAff × 0.11983.1.S1_at | TLR3 | toll-like receptor 3 | 7.9 | 6.4 | 2.2 | 0.181332902 |
| CfaAff × 0.18172.1.S1_at | TLR7 | Toll-like receptor 7 | 7.1 | 5.8 | 2.4 | 0 |
| Acute Phase Proteins | ||||||
| CfaAff × 0.23392.1.S1_x_at | SAA | serum amyloid A protein | 7.2 | 5.8 | 3.8 | 0 |
| *Cfa.3173.2.A1_a_at | SAA1* | serum amyloid A1 | 7.9 | 4.8 | 20.1 | 0 |
| *Cfa.3173.2.A1_a_at | SAA2* | serum amyloid A2 | 7.9 | 4.8 | 20.1 | 0 |
| Cfa.5989.1.A1_s_at | SERPINA1 | “serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1” | 7.9 | 6.5 | 2.2 | 0 |
| *Cfa.14503.1.A1_at | SERPINA3* | “serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3” | 9.7 | 7.2 | 5.7 | 0 |
| *Cfa.5199.1.A1_at | STAT3* | signal transducer and activator of transcription 3 | 9.6 | 8.3 | 2.4 | 0 |
| Apoptosis | ||||||
| CfaAff × 0.7867.1.S1_s_at | APOE | apolipoprotein E | 11.8 | 9.5 | 4.4 | 0 |
| Cfa.110.1.S1_s_at | BCL2 | B-cell CLL/lymphoma 2 | 9.1 | 7.7 | 2.6 | 0 |
| *Cfa.21056.1.S1_at | BCL2A1* | BCL2-related protein A1 | 8.3 | 6.2 | 5.4 | 0 |
| Cfa.3589.1.S1_s_at | CASP4 | “caspase 4, apoptosis-related cysteine peptidase” | 8.4 | 6.3 | 3.7 | 0 |
| Cfa.3851.1.S1_s_at | CCL2 | chemokine (C-C motif) ligand 2 | 7.8 | 6.2 | 4.7 | 0 |
| CfaAff × 0.29633.1.S1_s_at | GADD45B | “growth arrest and DNA-damage-inducible, beta” | 9.1 | 7.3 | 3.2 | 0 |
| CfaAff × 0.16351.1.S1_s_at | IFIH1 | interferon induced with helicase C domain 1 | 7.9 | 6.7 | 2.3 | 0 |
| Cfa.40.1.S1_s_at | IL18 | interleukin 18 (interferon-gamma-inducing factor) | 6.9 | 5.5 | 2.5 | 0 |
| Cfa.13715.1.A1_at | LOC479458 | similar to caspase 12 (mouse) | 7.0 | 4.8 | 4.4 | 0 |
| CfaAff × 0.15920.1.S1_s_at | MX1 | “myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)” | 11.0 | 9.7 | 2.2 | 0 |
| CfaAff × 0.23506.1.S1_at | NTF3 | neurotrophin 3 | 7.2 | 5.9 | 3.3 | 0 |
| *Cfa.9240.1.S1_at | SPP1* | secreted phosphoprotein 1 (osteopontin) | 9.7 | 6.3 | 9.2 | 0 |
| *Cfa.18084.1.S1_s_at | STAT1* | signal transducer and activator of transcription 1 | 7.8 | 6.2 | 3.0 | 0 |
| Cfa.18359.1.S1_at | STK17B | serine/threonine kinase 17b | 7.9 | 6.9 | 2.2 | 0 |
| *CfaAff × 0.12369.1.S1_s_at | SULF1* | sulfatase 1 | 8.8 | 7.5 | 2.1 | 0 |
| Cfa.6225.1.A1_at | TNFRSF14 | “tumor necrosis factor receptor superfamily, member 14” | 8.3 | 7.1 | 2.2 | 0 |
| CfaAff × 0.23380.1.S1_s_at | TNFRSF1A | “tumor necrosis factor receptor superfamily, member 1A” | 7.4 | 6.3 | 2.1 | 0 |
| Protein degradation | ||||||
| *CfaAff × 0.14173.1.S1_s_at | CTSC* | cathepsin C | 11.4 | 8.2 | 7.9 | 0 |
| *Cfa.2521.1.S1_at | CTSH* | cathepsin H | 12.0 | 10.0 | 3.5 | 0 |
| *Cfa.1661.1.S1_at | CTSS* | cathepsin S | 11.5 | 9.1 | 4.6 | 0 |
| CfaAff × 0.18934.1.S1_at | CTSZ | cathepsin Z | 8.3 | 6.9 | 2.4 | 0 |
| Cfa.4392.1.S1_at | DNASE2 | “deoxyribonuclease II, lysosomal” | 9.8 | 8.5 | 2.2 | 0 |
| Cfa.10080.1.A1_at | LAMP2 | lysosomal-associated membrane protein 2 | 9.8 | 8.5 | 2.0 | 0.181332902 |
| *Cfa.9004.1.S1_at | LAPTM5* | lysosomal associated multispanning membrane protein 5 | 10.4 | 8.3 | 3.9 | 0 |
| *Cfa.11935.1.A1_at | LGMN* | legumain | 9.1 | 8.1 | 2.1 | 0 |
| *Cfa.797.1.S1_at | LGALS3 | “lectin, galactoside-binding, soluble, 3” | 11.9 | 10.5 | 2.4 | 0 |
| CfaAff × 0.9252.1.S1_at | LGALS3BP | “lectin, galactoside-binding, soluble, 3 binding protein” | 7.9 | 6.7 | 2.3 | 0 |
| *Cfa.15305.1.S1_at | LYZ* | lysozyme | 10.5 | 7.9 | 5.2 | 0 |
| CfaAff × 0.7537.1.S1_at | PRSS23 | “protease, serine, 23” | 9.3 | 8.1 | 2.1 | 0 |
| *Cfa.12298.1.A1_a_at | PSMB8* | “proteasome subunit, beta type, 8” | 8.9 | 7.2 | 3.6 | 0 |
| Antigen processing/presentation | ||||||
| CfaAff × 0.21053.1.S1_s_at | B2M | beta-2-microglobulin | 13.1 | 11.9 | 2.2 | 0 |
| *Cfa.20996.1.S1_at | DLA-12* | MHC class I DLA-12 | 12.2 | 10.3 | 3.7 | 0 |
| CfaAff × 0.1704.1.S1_s_at | DLA-64 | MHC class I DLA-64 | 8.7 | 6.2 | 5.6 | 0 |
| *Cfa.14528.1.A1_at | DLA-79* | MHC class Ib | 10.2 | 8.3 | 3.8 | 0 |
| *Cfa.280.1.S1_s_at | dla88* | MHC class I DLA-88 | 13.6 | 12.2 | 2.6 | 0 |
| *Cfa.182.1.S1_s_at | DLA-DQA1* | “major histocompatibility complex, class II, DQ alpha 1” | 7.7 | 5.4 | 5.1 | 0 |
| CfaAff × 0.2152.1.S1_s_at | DLA-DQB1 | “major histocompatibility complex, class II, DQ beta 1” | 10.4 | 7.3 | 9.0 | 0 |
| *Cfa.6456.1.S1_at | DLA-DRA1* | MHC class II DR alpha chain | 12.0 | 9.3 | 6.2 | 0 |
| Cfa.181.1.S1_at | DLA-DRB1 | MHC class II DLA DRB1 beta chain | 12.3 | 9.5 | 6.1 | 0 |
| Cfa.173.1.A1_s_at | FCGR1A | “Fc fragment of IgG, high affinity Ia, receptor (CD64)” | 8.9 | 6.6 | 4.5 | 0 |
| *Cfa.21258.1.S1_at | FCGR3A* | “Fc fragment of IgG, low affinity IIIa, receptor (CD16a)” | 8.0 | 5.2 | 6.9 | 0 |
| *Cfa.17806.1.S1_at | FCGRT* | “Fc fragment of IgG, receptor, transporter, alpha” | 9.9 | 8.7 | 2.3 | 0 |
| *Cfa.18297.1.S1_at | HLA-DMA* | “major histocompatibility complex, class II, DM alpha” | 9.2 | 7.2 | 3.9 | 0 |
| Inflammation | ||||||
| CfaAff × 0.11797.1.S1_s_at | ACOX2 | “acyl-Coenzyme A oxidase 2, branched chain” | 8.7 | 7.0 | 2.7 | 0 |
| Cfa.14366.1.S1_s_at | AIF1 | allograft inflammatory factor 1 | 8.6 | 7.3 | 2.4 | 0 |
| *Cfa.10210.1.S1_at | ALOX5AP* | arachidonate 5-lipoxygenase-activating protein | 9.7 | 8.1 | 2.8 | 0 |
| *Cfa.19174.1.S1_s_at | CD163* | CD163 molecule | 6.4 | 5.0 | 2.2 | 0 |
| *Cfa.6017.1.S1_at | CYBB* | “cytochrome b-245, beta polypeptide” | 8.4 | 6.0 | 5.3 | 0 |
| Cfa.3634.1.S1_at | ITGB2 | “integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)” | 8.1 | 6.8 | 2.2 | 0 |
| Cfa.12422.1.A1_at | MGST2 | microsomal glutathione S-transferase 2 | 6.5 | 5.3 | 2.5 | 0 |
| CfaAff × 0.9427.1.S1_at | TNFAIP6 | “tumor necrosis factor, alpha-induced protein 6” | 10.5 | 9.0 | 2.8 | 0 |
| *CfaAff × 0.3283.1.S1_s_at | TREM2* | triggering receptor expressed on myeloid cells 2 | 7.8 | 6.4 | 2.8 | 0 |
| T and B cell proteins | ||||||
| *Cfa.14560.1.S1_at | CD48* | CD48 molecule | 7.8 | 5.9 | 4.0 | 0 |
| Cfa.3629.2.S1_s_at | CD86 | CD86 molecule | 9.9 | 8.0 | 3.8 | 0 |
| Cfa.12433.1.A1_at | CD99 | CD99 molecule | 10.2 | 8.9 | 2.0 | 0 |
| CfaAff × 0.20171.1.S1_s_at | FCRLA | Fc receptor-like A | 8.5 | 5.3 | 8.4 | 0 |
| CfaAff × 0.11449.1.S1_at | ID1 | inhibitor of DNA binding 1 | 8.9 | 7.9 | 2.1 | 0 |
| *Cfa.64.1.S1_at | ID3* | inhibitor of DNA binding 3 | 10.3 | 8.7 | 2.9 | 0 |
| Cfa.4556.2.S1_s_at | IGHAC | IgA heavy chain constant region | 7.1 | 5.6 | 3.7 | 0.181332902 |
| Cfa.4556.3.A1_s_at | LOC607467 | Ig heavy chain V-III region VH26 precursor | 7.9 | 5.8 | 5.7 | 0.181332902 |
| Cfa.15473.1.A1_at | LY86 | lymphocyte antigen 86 | 7.8 | 6.6 | 2.0 | 0 |
| *Cfa.19790.1.S1_at | NFAT5* | “nuclear factor of activated T-cells 5, tonicity-responsive” | 9.3 | 8.2 | 2.1 | 0 |
| Cfa.17809.1.S1_s_at | PTPRC | “protein tyrosine phosphatase, receptor type, C” | 6.3 | 5.0 | 2.4 | 0 |
| Cfa.11351.1.A1_at | TCIRG1 | “T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3” | 8.7 | 7.5 | 2.2 | 0 |
| Growth Factors, growth factor binding proteins, and their receptors | ||||||
| *Cfa.17361.1.S1_s_at | CSF1R* | colony stimulating factor 1 receptor | 9.6 | 6.4 | 11.1 | 0 |
| CfaAff × 0.9754.1.S1_s_at | LTBP1 | latent transforming growth factor beta binding protein 1 | 7.3 | 5.9 | 2.5 | 0 |
| Cfa.18699.1.S1_s_at | LTBP3 | latent transforming growth factor beta binding protein 3 | 8.5 | 7.3 | 2.2 | 0 |
| Cfa.10765.1.S1_s_at | PDGFRA | “platelet-derived growth factor receptor, alpha polypeptide” | 8.4 | 7.3 | 2.2 | 0 |
| CfaAff × 0.2176.1.S1_at | TNFRSF11B | “tumor necrosis factor receptor superfamily, member 11b” | 8.0 | 6.4 | 2.3 | 0 |
| Chemokine ligands and receptors | ||||||
| CfaAff × 0.21302.1.S1_s_at | CCR5 | chemokine (C-C motif) receptor 5 | 7.4 | 5.9 | 3.4 | 0.181332902 |
| *Cfa.16590.1.S1_s_at | CXCL10* | chemokine (C-X-C motif) ligand 10 | 6.9 | 4.7 | 9.5 | 0.181332902 |
| *Cfa.20779.1.S1_at | CXCL12* | chemokine (C-X-C motif) ligand 12 | 8.5 | 7.1 | 4.0 | 0 |
| CfaAff × 0.24352.1.S1_at | CXCL16 | chemokine (C-X-C motif) ligand 16 | 8.0 | 5.9 | 4.7 | 0 |
| Cfa.14516.1.S1_at | IL18BP | interleukin 18 binding protein | 9.4 | 7.8 | 3.4 | 0 |
| Extracellular Matrix Constituents | ||||||
| Cfa.10374.1.A1_at | COL12A1 | “collagen, type XII, alpha 1” | 6.8 | 4.8 | 4.2 | 0 |
| *Cfa.6936.1.A1_at | COMP* | cartilage oligomeric matrix protein | 7.7 | 6.6 | 2.5 | 0 |
| *Cfa.15083.1.S1_at | EFEMP1* | fibulin 3 | 8.7 | 7.6 | 2.0 | 0 |
| *Cfa.4189.1.A1_at | EFEMP2* | fibulin 4 | 11.4 | 10.2 | 2.2 | 0 |
| *Cfa.19661.1.S1_s_at | FBLN5* | fibulin 5 | 8.0 | 6.5 | 2.2 | 0 |
| *Cfa.5998.1.A1_x_at | FGG* | fibrinogen gamma chain | 8.0 | 6.7 | 3.4 | 0 |
| CfaAff × 0.1090.1.S1_at | MMP19 | matrix metallopeptidase 19 | 7.1 | 5.6 | 2.3 | 0 |
| Cfa.19828.1.S1_at | LOC475881 | Neuronal cell adhesion molecule precursor (Nr-CAM) | 9.5 | 8.5 | 2.0 | 0 |
| Misc. Molecules | ||||||
| CfaAff × 0.20132.1.S1_at | ACE | angiotensin I converting enzyme 1 | 9.7 | 7.4 | 4.7 | 0 |
| Cfa.3982.1.A1_at | AGT | angiotensinogen | 8.0 | 6.6 | 3.2 | 0 |
| *Cfa.2878.1.A1_s_at | CP* | ceruloplasmin (ferroxidase) | 11.0 | 7.6 | 10.4 | 0 |
| *Cfa.19821.1.S1_s_at | GFAP* | glial fibrillary acidic protein | 7.0 | 5.2 | 3.3 | 0 |
| CfaAff × 0.9311.1.S1_s_at | GMFG | “glia maturation factor, gamma” | 9.2 | 7.9 | 2.5 | 0 |
| Cfa.19828.1.S1_at | LOC475881 | similar to Neuronal cell adhesion molecule precursor (Nr-CAM) | 9.5 | 8.5 | 2.0 | 0 |
| *Cfa.10277.1.S1_at | S100A1* | S100 calcium binding protein A1 | 10.9 | 9.6 | 2.3 | 0 |