Table 3 of Jiang, Mol Vis 2010; 16:2092-2108.


Table 3. Selected genes detected at decreased levels in the glaucomatous canine retina.

Probe Set ID Gene Annotation Glau_avg Cont_avg Fold Change q-value(%)
RGC genes
CfaAff × 0.30898.1.S1_at CALB2 “calbindin 2, (calretinin)” 7.4 9.5 3.8 0
CfaAff × 0.29820.1.S1_s_at CIRBP cold inducible RNA binding protein 9.0 10.3 2.3 0
CfaAff × 0.27495.1.S1_at CPLX3 complexin 3 9.1 10.5 2.3 0
Cfa.12330.1.A1_s_at EBF1 early B-cell factor 1 5.1 7.2 4.3 0
Cfa.9181.1.A1_at ELAVL2 “ELAV (embryonic lethal, abnormal vision)-like 2” 6.7 9.2 4.6 0
Cfa.19294.1.S1_s_at ELAVL4 “ELAV (embryonic lethal, abnormal vision)-like 4” 6.1 9.2 6.3 0
*Cfa.299.1.A1_at FABP3* “fatty acid binding protein 3, muscle and heart” 7.6 9.4 2.9 0
Cfa.1153.1.A1_at FKBP1B “FK506 binding protein 1B, 12.6 kDa” 8.3 10.2 3.5 0
*Cfa.5865.1.A1_at KIF5A* kinesin family member 5A 6.7 8.5 2.8 0
Cfa.10948.1.S1_at LOC610447 Visinin-like protein 1 (VILIP) 7.5 11.5 9.9 0
*CfaAff × 0.19019.1.S1_s_at NEFH* “neurofilament, heavy polypeptide 200kDa” 6.6 7.9 2.3 0
Cfa.10952.1.A1_s_at NEFL “neurofilament, light polypeptide 68kDa” 8.6 12.6 9.3 0
*Cfa.10905.1.A1_at NEFM* “neurofilament, medium polypeptide 150kDa” 8.8 12.9 10.3 0
*Cfa.11184.1.A1_s_at NELL2* NEL-like 2 (chicken) 6.9 8.8 3.7 0
Cfa.9043.1.A1_at NRG1 neuregulin 1 6.3 7.4 2.2 0
CfaAff × 0.14934.1.S1_at NRN1 neuritin 1 6.6 9.2 5.5 0
Cfa.12391.1.A1_s_at RBPMS RNA binding protein with multiple splicing 6.8 7.7 2.0 0
*CfaAff × 0.11569.1.S1_s_at SCN1B* “sodium channel, voltage-gated, type I, beta” 6.0 7.4 2.7 0
*CfaAff × 0.13307.1.S1_s_at STMN2* stathmin-like 2 8.9 10.4 3.1 0
*Cfa.4489.1.S1_at UCHL1* ubiquitin carboxyl-terminal esterase L1 11.4 12.7 2.6 0
Synapse and Synaptic Transmission
*CfaAff × 0.21696.1.S1_at ACHE* acetylcholinesterase 6.0 7.4 2.4 0
CfaAff × 0.11508.1.S1_s_at CADPS Ca2+dependent secretion activator 8.6 10.4 3.3 0
CfaAff × 0.18352.1.S1_s_at CPNE6 copine VI (neuronal) 6.8 7.9 2.1 0
Cfa.9427.1.A1_at CRH corticotropin releasing hormone 6.5 8.6 3.8 0
Cfa.21295.1.S1_s_at DRD1IP dopamine receptor D1 interacting protein 7.3 9.5 4.6 0
CfaAff × 0.4606.1.S1_at GABBR2 “gamma-aminobutyric acid (GABA) B receptor, 2” 6.4 7.5 2.1 0
CfaAff × 0.26365.1.S1_at GABRA1 “gamma-aminobutyric acid (GABA) A receptor, alpha 1” 5.4 7.7 4.3 0
*Cfa.11206.1.A1_at GABRB3* “gamma-aminobutyric acid (GABA) A receptor, beta 3” 6.8 9.5 5.4 0
CfaAff × 0.26360.1.S1_s_at GABRG2 “gamma-aminobutyric acid (GABA) A receptor, gamma 2” 6.3 8.4 4.1 0
CfaAff × 0.5585.1.S1_s_at GABRR1 “gamma-aminobutyric acid (GABA) receptor, rho 1” 6.3 8.8 5.2 0
*Cfa.1206.2.A1_s_at GAD1* “glutamate decarboxylase 1 (brain, 67kDa)” 5.7 8.1 4.4 0
*CfaAff × 0.13687.1.S1_at GRIA2* “glutamate receptor, ionotropic, AMPA 2” 7.4 9.1 3.4 0
CfaAff × 0.22871.1.S1_at GRIA4 “glutamate receptor, ionotrophic, AMPA 4” 6.2 7.6 2.5 0
CfaAff × 0.3513.1.S1_at GRM8 “glutamate receptor, metabotropic 8” 5.2 7.8 5.5 0
CfaAff × 0.4263.1.S1_s_at ICA1 “islet cell autoantigen 1, 69kDa” 6.1 7.6 2.7 0
Cfa.9545.1.A1_at NOVA1 neuro-oncological ventral antigen 1 7.0 8.2 2.3 0
CfaAff × 0.28644.1.S1_at RAB33A “RAB33A, member RAS oncogene family” 7.1 8.2 2.1 0
CfaAff × 0.11242.1.S1_s_at SYNPR synaptoporin 6.0 8.2 4.1 0
CfaAff × 0.18684.1.S1_s_at SYT14 synaptotagmin XIV 6.5 7.8 2.6 0
CfaAff × 0.27070.1.S1_at SYT4 synaptotagmin IV 5.5 7.3 3.7 0
Cfa.4050.1.A1_a_at TAC1 “tachykinin, precursor 1” 6.1 8.2 3.4 0
Phototransduction
CfaAff × 0.25681.1.S1_at ARR3 “arrestin 3, retinal (X-arrestin)” 10.3 12.9 2.1 0
Cfa.3480.1.A1_s_at GNGT2 “guanine nucleotide binding protein, gamma” 10.3 12.3 2.4 0.064323389
CfaAff × 0.3367.1.S1_at OPN1SW “opsin 1, short-wave-sensitive” 7.6 10.6 3.5 0.064323389
CfaAff × 0.12695.1.S1_s_at PDE6C cGMP-specific phosphodiesterase 6C 7.1 8.6 2.0 0.064323389
Synucleins
*CfaAff × 0.15497.1.S1_s_at SNCA* “synuclein, alpha “ 5.8 7.4 2.9 0
*CfaAff × 0.25469.1.S1_s_at SNCB* “synuclein, beta” 7.1 8.5 2.3 0
CfaAff × 0.24686.1.S1_at SNCG “synuclein, gamma” 5.9 8.5 5.1 0
Growth Factors
Cfa.19396.1.S1_s_at FGF12 fibroblast growth factor 12 5.5 7.0 2.9 0
*CfaAff × 0.9858.1.S1_s_at FGF14* fibroblast growth factor 14 6.8 8.0 2.2 0
*Cfa.3888.1.S1_at IGF1* insulin-like growth factor 1 (somatomedin C) 4.8 6.5 3.5 0
CfaAff × 0.2203.1.S1_at IL5 “interleukin 5 (colony-stimulating factor, eosinophil)” 5.0 7.2 4.4 0
*Cfa.4064.1.A1_at PTN* pleiotrophin (neurite growth-promoting factor 1) 6.4 8.4 4.5 0
Cell Adhesion
CfaAff × 0.14553.1.S1_at AMIGO2 adhesion molecule with Ig-like domain 2 6.4 8.1 3.2 0
CfaAff × 0.29067.1.S1_at CDH12 “cadherin 12, type 2 (N-cadherin 2)” 6.1 7.7 2.9 0
CfaAff × 0.29091.1.S1_at CDH18 “cadherin 18, type 2” 5.6 7.4 3.4 0
CfaAff × 0.1039.1.S1_at CDH7 “cadherin 7, type 2” 7.4 8.6 2.4 0
Cfa.9512.1.A1_at CTNNA2 “catenin (cadherin-associated protein), alpha 2” 7.3 8.8 3.1 0
Cfa.3718.1.S1_s_at DSC2 desmocollin 2 6.1 7.4 3.0 0
CfaAff × 0.13441.1.S1_s_at EDIL3 EGF-like repeats and discoidin I-like domains 3 5.6 7.3 2.7 0
Cfa.2219.1.A1_at ITGA6 “integrin, alpha 6” 7.5 8.3 2.2 0
*CfaAff × 0.8342.1.S1_at PCDH9* protocadherin 9 6.4 7.7 2.5 0
Cfa.9146.1.A1_at PCDHAC2 “protocadherin alpha subfamily C, 2” 7.0 8.8 3.3 0
Cfa.9467.1.A1_at RELN reelin 8.4 9.6 2.5 0
Calcium Binding
*Cfa.7840.1.A1_at CABP5* calcium binding protein 5 8.6 11.2 4.7 0
*CfaAff × 0.14235.1.S1_s_at CALB1* “calbindin 1, 28kDa” 6.3 10.0 6.8 0
Cfa.4168.2.S1_s_at CALM1 “calmodulin 1 (phosphorylase kinase, delta)” 10.2 11.2 2.4 0
Cfa.20415.1.S1_at HPCA hippocalcin 7.4 8.9 2.6 0
Cfa.10160.1.S1_at PPP3CA “protein phosphatase 3, catalytic subunit, alpha isoform” 9.3 10.2 2.1 0
Cfa.10339.1.S1_at PPP3R1 “protein phosphatase 3, regulatory subunit B, alpha isoform” 8.3 9.5 2.4 0
Cfa.10159.1.S1_at PRKCB1 “protein kinase C, beta 1” 8.0 9.8 4.3 0
*Cfa.20981.1.S1_s_at PVALB* parvalbumin 7.7 12.1 12.0 0
Calcium Channels
*Cfa.1728.1.A1_s_at CACNA2D3* “Ca channel, voltage-dependent, alpha 2/delta 3 subunit” 6.3 8.5 4.2 0
Cfa.1210.1.S1_at CACNB3 “Ca channel, voltage-dependent, beta 3 subunit” 7.2 8.3 2.6 0
Cfa.269.1.A1_at RYR2 ryanodine receptor 2 5.3 7.0 3.2 0
CfaAff × 0.7090.1.S1_s_at TRPC3 “transient receptor potential cation channel, subfamily C, member 3” 5.5 7.6 4.4 0
*CfaAff × 0.16161.1.S1_s_at TRPM1* “transient receptor potential cation channel, subfamily M, member 1” 8.0 9.8 4.6 0
Neuronal Development
*Cfa.9271.1.A1_at CA10* carbonic anhydrase X 7.3 10.0 6.1 0
Cfa.10284.1.S1_s_at CRMP1 collapsin response mediator protein 1 6.1 7.1 2.1 0
CfaAff × 0.16492.1.S1_at DNER delta/notch-like EGF repeat containing 8.8 9.7 2.0 0
Cfa.19360.1.S1_s_at GNAO1 “guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O” 8.9 10.8 3.8 0
Cfa.7236.1.A1_s_at NRXN1 neurexin 1 7.1 9.4 4.2 0
*Cfa.10306.1.S1_at OLFM1* olfactomedin 1 8.6 10.0 2.5 0
CfaAff × 0.30602.1.S1_at OLFM3 olfactomedin 3 5.8 7.1 2.9 0
*Cfa.9934.1.A1_at PCP4* Purkinje cell protein 4 9.6 13.0 8.9 0
Cfa.15689.1.A1_at PHYH phytanoyl-CoA 2-hydroxylase 7.1 9.2 4.3 0
CfaAff × 0.12766.1.S1_at ROBO2 “roundabout, axon guidance receptor, homolog 2” 5.8 7.8 4.2 0
*CfaAff × 0.22493.1.S1_s_at SERPINI1* “serpin peptidase inhibitor, clade I, member 1” 10.0 11.8 3.0 0
*Cfa.10644.1.A1_at SH3GL3* SH3-domain GRB2-like 3 6.8 9.0 5.2 0
*Cfa.1224.1.S1_at TAGLN3* transgelin 3 9.2 11.9 4.9 0
Cfa.174.1.S1_s_at TFAP2B transcription factor AP-2 beta 6.9 9.6 4.4 0
Transcription Factors
CfaAff × 0.12012.1.S1_at GTF2H3 “general transcription factor IIH, polypeptide 3, 34kDa” 5.8 6.8 2.0 0.126704939
CfaAff × 0.28228.1.S1_at ISL1 ISL LIM homeobox 1 6.2 7.6 2.9 0
CfaAff × 0.5793.1.S1_s_at MYT1L myelin transcription factor 1-like 5.5 6.8 2.4 0
CfaAff × 0.25541.1.S1_s_at RORA RAR-related orphan receptor A 5.6 6.8 2.1 0.064323389
Cfa.5127.1.A1_s_at RUNX1T1 runt-related transcription factor 1 6.6 8.1 2.8 0
*CfaAff × 0.20645.1.S1_at RXRG* “retinoid X receptor, gamma” 7.0 8.1 2.0 0
G-protein coupled receptor protein signaling
Cfa.11087.1.A1_s_at BAI3 brain-specific angiogenesis inhibitor 3 7.2 8.9 3.3 0
*CfaAff × 0.8825.1.S1_s_at CCK* cholecystokinin 5.4 7.2 2.7 0.126704939
Cfa.3870.1.A1_at GAL galanin prepropeptide 5.6 8.0 5.5 0
*Cfa.3177.1.S1_at GNAI1* “guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1” 9.8 11.2 2.8 0
*Cfa.10270.2.A1_at GNG3* “guanine nucleotide binding protein (G protein), gamma 3” 7.5 9.5 3.6 0
CfaAff × 0.5919.1.S1_at GPR85 G protein-coupled receptor 85 7.0 9.0 4.2 0
CfaAff × 0.4269.1.S1_at NXPH1 neurexophilin 1 6.2 8.9 5.4 0
*Cfa.9688.1.A1_at NXPH2* neurexophilin 2 5.8 7.2 2.6 0
Cfa.1416.1.A1_at PENK proenkephalin 5.7 7.4 3.2 0
Cfa.11233.1.A1_at SSTR2 somatostatin receptor 2 5.9 7.0 2.3 0.064323389
Cytoskeleton
CfaAff × 0.5843.1.S1_s_at ELMO1 engulfment and cell motility 1 6.8 8.8 5.0 0
Cfa.6416.1.A1_at SGCG “sarcoglycan, gamma” 6.0 7.0 2.1 0
*Cfa.11292.1.A1_at TMOD1* tropomodulin 1 6.9 8.8 3.0 0
*Cfa.10164.1.S1_at TUBA4A* “tubulin, alpha 4a” 7.1 9.8 4.9 0
*Cfa.11276.1.S1_s_at TUBB2A* “tubulin, beta 2A” 11.1 12.9 3.3 0