Figure 7. pBTLA plasmid treatment suppresses the systemic DTH responses of mice. pBTLA and pcDNA3.1 treated mice received 100 µg of the respective plasmid on days −7, 0, 7 relative to HSV-1 corneal inoculation, PBS treated mice received 100 µl PBS i.p. Two weeks after viral infection, DTH responses were measured in the footpad. All infected groups (n=6 in each group) had significant responses compared with the uninfected control mice (*p<0.01). DTH responses in pBTLA treated mice were lower than in pcDNA3.1 or PBS control mice (^#p<0.01).