Figure 1. Pedigree diagram of the Autosomal Dominant Optic Atrophy (ADOA) family. The pedigree of a five-generation family shows eighteen affected members. Solid squares mean male patients, open circles mean normal females, solid circles mean female patients, open squares mean normal males, arrow means proband (V-3). Oblique lines through circles and squares represent deceased, vertical lines indicate the presence of the mutation in two unaffected family members (IV-7 and IV-10) and in another family member not available for ophthalmological examination (V-15).