Figure 1. H-RN inhibits endothelial cells (EC) proliferation while H-FT does not. A: After 24 h of starvation, rhesus macaque choroid-retina endothelial (RF/6A) cells were incubated in vascular endothelial growth factor (VEGF) and various concentrations of bevacizumab or peptides for 24 h; RF/6A cell proliferation was inhibited by bevacizumab and H-RN. An H-RN concentration of 1 mM inhibited the VEGF-induced response significantly. However, the inhibitory effect was not as strong as bevacizumab’s. H-FT and scrambled peptide had no inhibitory activity on RF/6A cells at various concentrations (**p<0.01, each condition versus control). B: Compared to the culture medium group, cell viability was not affected by H-RN alone at any concentration tested (p>0.05, each condition versus control.)