Table 5 of Tong, Mol Vis 2010; 16:1958-1981. Table 5 of Tong, Mol Vis 2010; 16:1958-1981.
Table 5. Age related macular degeneration (AMD): HTRA1 SNPs versus ARMS2 single nucleotide polymorphisms (SNPs).
| Comparison | No. of studies | Total sample size (n) | Bayesian random effects | Fixed effects | Random effects | Heterogeneity | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Odds ratio | 95% credible interval | Odds ratio | 95% CI | Odds ratio | 95% CI | Q | P value | I2 (%) | |||
| HTRA1 (rs11200638) | |||||||||||
| A allele versus G allele | |||||||||||
| Total | 16 | 4034/3212 | / | / | 2.664 | 2.476, 2.867 | 2.803 | 2.486, 3.159 | 34.576 | 0.003 | 56.6 |
| HWE | 14 | 3124/2784 | / | / | 2.754 | 2.542, 2.984 | 2.909 | 2.547, 3.324 | 30.471 | 0.004 | 57.4 |
| Adjusted HWE | 16 | 4034/3212 | / | / | 2.701 | 2.510, 2.907 | 2.827 | 2.519, 3.173 | 31.923 | 0.007 | 53 |
| East Asian | 7 | 835/868 | / | / | 2.847 | 2.473, 3.278 | 2.847 | 2.473, 3.278 | 4.873 | 0.56 | 0 |
| Caucasian | 8 | 2970/2160 | / | / | 2.589 | 2.366, 2.833 | 2.8 | 2.289, 3.424 | 28.452 | 0 | 75.4 |
| Seven studies with 2 SNPs | 7 | 1533/1206 | / | / | 3.059 | 2.717, 3.444 | 3.053 | 2.681, 3.478 | 7.028 | 0.318 | 14.7 |
| AA versus GG | |||||||||||
| Total | 16 | 4034/3212 | 7.972 | 6.453, 9.778 | 7.21 | 6.035, 8.614 | 7.737 | 6.096, 9.821 | 24.308 | 0.06 | 39.2 |
| HWE | 14 | 3124/2784 | 8.424 | 6.667, 10.540 | 7.515 | 6.201, 9.107 | 8.16 | 6.314, 10.546 | 20.51 | 0.083 | 37.6 |
| Adjusted HWE | 16 | 4034/3212 | 8.225 | 6.700, 10.030 | 7.423 | 6.205, 8.880 | 7.928 | 6.286, 10.000 | 22.776 | 0.089 | 35.3 |
| East Asian | 7 | 835/868 | 7.604 | 5.541, 10.100 | 7.273 | 5.390, 9.815 | 7.273 | 5.390, 9.815 | 4.27 | 0.64 | 0 |
| Caucasian | 8 | 2970/2160 | 8.691 | 5.813, 13.600 | 7.258 | 5.719, 9.211 | 8.687 | 5.556, 13.582 | 19.969 | 0.006 | 65.8 |
| Wet AMD | 8 | 1348/1212 | 9.484 | 6.834, 12.800 | 9.205 | 6.941, 12.207 | 9.843 | 6.539, 14.817 | 14.147 | 0.049 | 51.6 |
| Wet AMD + Dry AMD | 8 | 2686/2000 | 6.561 | 5.137, 8.270 | 6.138 | 4.881, 7.719 | 6.138 | 4.881, 7.719 | 5.391 | 0.612 | 0 |
| Seven studies investigated 2 SNPs | 7 | 1533/1206 | 8.967 | 5.964, 12.920 | 8.534 | 6.411, 11.360 | 9.309 | 5.924, 14.682 | 14.097 | 0.029 | 58.8 |
| AG versus GG | |||||||||||
| Total | 16 | 4034/3212 | 2.226 | 1.982, 2.496 | 2.168 | 1.944, 2.418 | 2.18 | 1.943, 2.447 | 15.784 | 0.397 | 5 |
| HWE | 14 | 3124/2784 | 2.28 | 2.006, 2.589 | 2.193 | 1.943, 2.475 | 2.232 | 1.935, 2.574 | 15.295 | 0.289 | 15.1 |
| Adjusted HWE | 16 | 4034/3212 | 2.252 | 2.011, 2.516 | 2.192 | 1.966, 2.445 | 2.204 | 1.962, 2.477 | 15.942 | 0.386 | 5.9 |
| East Asian | 7 | 835/868 | 2.277 | 1.781, 2.866 | 2.202 | 1.684, 2.878 | 2.219 | 1.665, 2.957 | 6.812 | 0.339 | 12.3 |
| Caucasian | 8 | 2970/2160 | 2.273 | 1.916, 2.741 | 2.205 | 1.948, 2.495 | 2.221 | 1.949, 2.531 | 7.453 | 0.383 | 6.1 |
| Wet AMD | 8 | 1348/1212 | 2.692 | 2.197, 3.249 | 2.706 | 2.231, 3.281 | 2.708 | 2.219, 3.305 | 7.311 | 0.397 | 4.3 |
| Wet AMD + Dry AMD | 8 | 2686/2000 | 1.959 | 1.723, 2.222 | 1.953 | 1.711, 2.230 | 1.953 | 1.711, 2.230 | 1.024 | 0.994 | 0 |
| Seven studies with 2 SNPs | 7 | 1533/1206 | 2.392 | 1.938, 2.907 | 2.396 | 2.004, 2.866 | 2.471 | 1.946, 3.138 | 9.387 | 0.153 | 36.2 |
| λ | |||||||||||
| Total | 0.386 | 0.343, 0.430 | |||||||||
| HWE | 0.387 | 0.340, 0.435 | |||||||||
| Adjusted HWE | 0.386 | 0.343, 0.429 | |||||||||
| East Asian | 0.403 | 0.311, 0.491 | |||||||||
| Caucasian | 0.381 | 0.327, 0.438 | |||||||||
| Wet AMD | 0.441 | 0.373, 0.510 | |||||||||
| Wet AMD + Dry AMD | 0.359 | 0.300, 0.419 | |||||||||
| Seven studies with 2 SNPs | 0.4 | 0.331, 0.471 | |||||||||
| LOC387715/ARMS2 (rs10490924) | |||||||||||
| T allele versus G allele | |||||||||||
| Total | 18 | 5027/5878 | / | / | 2.725 | 2.556, 2.906 | 2.734 | 2.366, 3.158 | 80.195 | 0 | 78.8 |
| HWE | 17 | 4893/5744 | / | / | 2.742 | 2.569, 2.928 | 2.761 | 2.376, 3.209 | 79.116 | 0 | 79.8 |
| Adjusted HWE | 18 | 5027/5878 | / | / | 2.715 | 2.547, 2.896 | 2.719 | 2.351, 3.145 | 81.68 | 0 | 79.2 |
| East Asian | 3 | 289/325 | / | / | 2.692 | 2.086, 3.315 | 2.692 | 2.086, 3.315 | 0.481 | 0.786 | 0 |
| Caucasian | 13 | 4425/4355 | / | / | 2.769 | 2.580, 2.972 | 2.794 | 2.333, 3.346 | 73.265 | 0 | 83.6 |
| Seven studies with 2 SNPs | 7 | 1471/1225 | / | / | 3.276 | 2.912, 3.686 | 3.211 | 2.711, 3.802 | 11.596 | 0.072 | 48.3 |
| TT versus GG | |||||||||||
| Total | 18 | 5027/5878 | 7.512 | 5.703, 9.659 | 7.096 | 6.069, 8.296 | 7.216 | 5.492, 9.480 | 48.208 | 0 | 65.3 |
| HWE | 17 | 4893/5744 | 7.826 | 5.886, 10.140 | 7.394 | 6.294, 8.683 | 7.533 | 5.707, 9.943 | 43.926 | 0 | 64.2 |
| Adjusted HWE | 18 | 5027/5878 | 7.51 | 5.692, 9.672 | 7.1 | 6.071, 8.303 | 7.209 | 5.483, 9.480 | 48.331 | 0 | 65.4 |
| East Asian | 3 | 289/325 | / | / | 6.934 | 4.206, 11.431 | 6.934 | 4.206, 11.431 | 1.232 | 0.54 | 0 |
| Caucasian | 13 | 4425/4355 | 7.57 | 5.326, 10.850 | 7.261 | 6.076, 8.677 | 7.41 | 5.176, 10.607 | 45.035 | 0 | 73.8 |
| Wet AMD | 7 | 1029/1073 | 8.567 | 5.509, 12.600 | 7.828 | 5.786, 10.582 | 8.273 | 5.191, 13.185 | 13.738 | 0.033 | 56.9 |
| Wet AMD + Dry AMD | 11 | 3998/4805 | 7.021 | 4.678, 9.950 | 6.846 | 5.703, 8.218 | 6.708 | 4.734, 9.505 | 33.919 | 0 | 71.1 |
| Seven studies with 2 SNPs | 7 | 1471/1225 | 9.767 | 6.169, 14.480 | 9.134 | 6.951, 12.002 | 9.521 | 5.922, 15.307 | 17.209 | 0.009 | 65.6 |
| GT versus GG | |||||||||||
| Total | 18 | 5027/5878 | 2.353 | 2.072, 2.665 | 2.336 | 2.134, 2.558 | 2.324 | 1.993, 2.709 | 42.812 | 0.001 | 60.3 |
| HWE | 17 | 4893/5744 | 2.38 | 2.093, 2.702 | 2.343 | 2.138, 2.569 | 2.336 | 1.990, 2.741 | 42.638 | 0 | 62.5 |
| Adjusted HWE | 18 | 5027/5878 | 2.334 | 2.058, 2.643 | 2.316 | 2.115, 2.535 | 2.29 | 1.956, 2.681 | 45.09 | 0 | 62.3 |
| East Asian | 3 | 289/325 | / | / | 1.843 | 1.203, 2.823 | 2.119 | 0.893, 5.029 | 7.783 | 0.02 | 74.5 |
| Caucasian | 13 | 4425/4355 | 2.424 | 2.062, 2.865 | 2.422 | 2.198, 2.669 | 2.445 | 2.082, 2.871 | 29.79 | 0.003 | 59.7 |
| Wet AMD | 7 | 1029/1073 | 2.519 | 1.983, 3.147 | 2.531 | 2.053, 3.122 | 2.519 | 1.813, 3.501 | 13.05 | 0.042 | 54 |
| Wet AMD + Dry AMD | 11 | 3998/4805 | 2.285 | 1.921, 2.694 | 2.293 | 2.074, 2.536 | 2.253 | 1.886, 2.691 | 29.067 | 0.001 | 65.6 |
| Seven studies with 2 SNPs | 7 | 1471/1225 | 2.507 | 1.999, 3.088 | 2.564 | 2.137, 3.076 | 2.567 | 2.065, 3.191 | 7.834 | 0.251 | 23.4 |
| λ | |||||||||||
| Total | 0.426 | 0.387, 0.467 | |||||||||
| HWE | 0.423 | 0.384, 0.463 | |||||||||
| Adjusted HWE | 0.422 | 0.383, 0.462 | |||||||||
| East Asian | / | / | |||||||||
| Caucasian | 0.438 | 0.395, 0.483 | |||||||||
| Wet AMD | 0.433 | 0.354, 0.513 | |||||||||
| Wet AMD + Dry AMD | 0.428 | 0.382, 0.475 | |||||||||
| Seven studies with 2 SNPs | 0.406 | 0.341, 0.472 | |||||||||