Table 2 of Tong, Mol Vis 2010; 16:1958-1981.

Table 2. Characteristics of case-control studies included in a meta-analysis of the association between the LOC387715 gene polymorphisms and AMD

Ref Year Region, country study was conducted Ethnicity Study design composition in cases (% males) Sex Mean age (years) Cases Controls Number of eligible subjects
Cases Controls Cases Controls
[106] 2007 Japan East Asian Case-control 79.5 75.7 71.2 Wet AMD Hospital-based controls without retinal diseases and AMD on the base of full ophthalmologic examination 73 94
[95] 2007 USA Caucasian Case-control NR >68.0 >68.0 Wet AMD+Dry AMD Without AMD on the base of full ophthalmologic examination 431 280
[99] 2007 France Caucasian Case-control NR >65.0 >65.0 Wet AMD Without any type of drusen, geographic atrophy, or exudative AMD. 118 116
[96] 2007 USA Caucasian Case-control NR 71.3 72.8 Wet AMD Without AMD on the base of full ophthalmologic examination 134 134
[100] 2007 UK Caucasian Case-control 40.6 >65.0 >65.0 Wet AMD Without AMD on the base of full ophthalmologic examination 401 266
[108] 2008 India Indian Asian Case-control NR 68.8 64.4 Wet AMD+Dry AMD Ethnic matched controls, without a family history of AMD or any other ocular or systemic diseases 193 203
[3] 2008 China East Asian Case-control 58.7 66 66.1 Wet AMD Without any AMD and any other major eye diseases aside from mild age-related cataracts 121 132
[84] 2005 Germany Caucasian Case-control NR NR NR Wet AMD+Dry AMD Without any AMD and any other major eye diseases 759 594
[84] 2005 Germany Caucasian Case-control 35.1 75.01 68.25 Wet AMD+Dry AMD Unrelated controls without any AMD and any other major eye diseases 361 328
[133] 2006 USA Caucasian Case-control 42 79.5 76.5 Wet AMD+Dry AMD Without AMD on the base of full ophthalmologic examination 693 172
[133] 2006 USA Mixed Case-control 44 73.2 70.3 Wet AMD+Dry AMD Without AMD on the base of full ophthalmologic examination 120 995
[56] 2007 Russia Caucasian Case-control 27.7 72.6 71.1 Wet AMD+Dry AMD Free of macular changes 155 151
?? 2007 Japan East Asian Case-control 70.5 73.4 73.6 Wet AMD Without any AMD 95 99
?? 2007 USA Caucasian Nested case-control 35.2 60.1 60.2 Wet AMD+Dry AMD Within 1 year of the same age with cases, and underwent eye examination in the past 2 years 445 1041
[128] 2007 USA Caucasian Case-control 42.6 79 72 Wet AMD+Dry AMD AMD free controls 399 329
[13] 2007 Australia Caucasian Cohort 39.9 75.6 74.9 Wet AMD+Dry AMD AMD free controls 278 557
[93] 2007 USA Caucasian Case-control NR NR NR Wet AMD Without any AMD 87 232
[83] 2008 USA Caucasian Case-control 39.6 79.1 72.9 Wet AMD+Dry AMD Without AMD on the base of full ophthalmologic examination 164 155

Tong, Mol Vis 2010; 16:1958-1981. http://www.molvis.org/molvis/v16/a213

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