Table 1 of Tong, Mol Vis 2010; 16:1958-1981. Table 1 of Tong, Mol Vis 2010; 16:1958-1981.
Table 1. Characteristics of case-control studies included in a meta-analysis of the association between the HTRA1 gene polymorphisms and AMD
| Ref | Year | Region, country study was conducted | Ethnicity | Study design | Sex composition in cases (% males) | Mean age (years) | Cases | Controls | Number of eligible subjects | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | Cases | Controls | ||||||||
| [101] | 2006 | China | East Asian | Case-control | 68 | 74.9 | 74.2 | Wet AMD | Age matched controls without AMD, confirmed by full ophthalmologic examination | 96 | 130 |
| [98] | 2007 | Austria | Caucasian | Case-control | 35.5 | 78 | 77.4 | Exudative AMD in AMD level 4 | Caucasians without AMD on the base of a detailed eye examination and fundus examination | 242 | 157 |
| [102] | 2007 | China | East Asian | Case-control | 45.1 | 64.0/ | 64 | Drusen, and wet AMD | Without any AMD, confirmed by a normal eye examination | 164 | 106 |
| [105] | 2007 | Japan | East Asian | Case-control | 72.4 | 71.9 | 67.9 | AMD, combined | Without AMD and unrelated to cases, confirmed by full ophthalmologic examination | 123 | 133 |
| [106] | 2007 | Japan | East Asian | Case-control | 79.5 | 75.7 | 71.2 | Wet AMD | Hospital-based controls without retinal diseases and AMD on the base of full ophthalmologic examination | 73 | 94 |
| [95] | 2007 | USA | Caucasian | Case-control | NR | >68.0 | >68.0 | AMD, combined | Without AMD on the base of full ophthalmologic examination | 535 | 288 |
| [99] | 2007 | France | Caucasian | Case-control | NR | >65.0 | >65.0 | Exudative AMD | Without any type of drusen, geographic atrophy, or exudative AMD. | 200 | 116 |
| [96] | 2007 | USA | Caucasian | Case-control | NR | 71.3 | 72.8 | Wet AMD | Without AMD on the base of full ophthalmologic examination | 134 | 134 |
| [100] | 2007 | UK | Caucasian | Case-control | 40.6 | >65.0 | >65.0 | Wet AMD | Without AMD on the base of full ophthalmologic examination | 401 | 266 |
| [97] | 2008 | USA | Caucasian | Case-control | 49.0/ 52.5/ 38.0/ 44.4 | 81.2/ 78.9/ 81.0/ 78.3 | 74 | bilateral wet AMD, unilateral wet AMD, bilateral GA, and unilateral GA. | Without any type of drusen, GA, AMD, and RPE | 776 | 294 |
| [103] | 2008 | China | East Asian | Case-control | 54 | 71.2 | 71.5 | Dry and wet AMD | Age and sex matched controls without any visual impairment, excluded a family history of AMD and any type of drusen, geographic atrophy, CNV, or other retinal disorder in either eye. | 95 | 90 |
| [104] | 2008 | China | East Asian | Case-control | 54 | 75.5 | 73.3 | Exudative AMD | Without any AMD and any other major eye diseases | 163 | 183 |
| [108] | 2008 | India | Indian Asian | Case-control | NR | 68.8 | 64.4 | AMD, combined | Ethnic matched controls, without a family history of AMD or any other ocular or systemic diseases | 250 | 250 |