Figure 2. Homology model of human myosin
VIIA showing the exon 16-encoded peptide in green in the middle of the
motor domain, which is colored in orange. This exon encodes the HW
helix [
22],
the
third strand of the central seven-stranded β-sheet, and the associated
loops. Wild-type methionine and mutant isoleucine 645 residues before
the SH2 helix (in orange) are represented as sticks and highlighted in
green and magenta, respectively. Structure visualization was done using
Pymol software.