Figure 2. Homology model of human myosin VIIA showing the exon 16-encoded peptide in green in the middle of the motor domain, which is colored in orange. This exon encodes the HW helix [22], the third strand of the central seven-stranded β-sheet, and the associated loops. Wild-type methionine and mutant isoleucine 645 residues before the SH2 helix (in orange) are represented as sticks and highlighted in green and magenta, respectively. Structure visualization was done using Pymol software.