Figure 6. Cataract phenotype in family JPM1. A: The eye picture shows a central opacity of both lenses of the female proband (III.2; 2.5 years). B: The central lens opacity appeared in 4 out of 7 siblings of seemingly healthy parents (generation I); one of the brothers
(generation II) transmitted the cataract to both his offspring (generation III) indicating an autosomal dominant mode of inheritance.
The mutation might have originated in the germ cells of the healthy grandparents (generation I).