Table 4 of Xu, Mol Vis 2010; 16:1823-1831.

Table 4. Inhibitory effect of structural analogs, organic cation and BCH on the uptake of L-[3H]carnitine by HCLE or HCjE cells.

    Relative uptake (% of control)
Compound Conc. (mM) HCLE HCjE
L-Carnitine 0.5 34.6±2.4 24.9±2.1
  1 14.9±3.2 11.7±1.5
D-Carnitine 0.5 46.6±3.1 43.9±1.9
  1 14.4±0.6 21.7±1.1
Acetyl-L-Carnitine 0.5 42.1±4.8 37.1±4.9
  1 20.9±4.1 25.6±5.7
γ-Butyrobetaine 0.5 30.2±5.3 27.5±4.8
  1 16.9±3.7 17.4±3.3
TEA 0.1 85.6±4.2 74.9±2.7
  1 48.3±5.1 59.2±1.4
BCH 0.1 87.1±0.7 84.5±4.4
  10 46.5±2.9 63.8±4.3

HCLE or HCjE cells were pre-incubated for 60 min in uptake buffer at 37 °C; L-[3H]carnitine (24 nM) was then added in the absence (control) or presence of L-carnitine, D-carnitine, Acetyl-L-carnitine, γ-Butyrobetaine, TEA and BCH, and the incubation continued for 30 min. Data (uptake of L-[3H]carnitine as a percentage of that in the control) are means±SD of results from three experiments. All results were significantly reduced compared to the controls (p<0.01).

Xu, Mol Vis 2010; 16:1823-1831. http://www.molvis.org/molvis/v16/a197

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