Table 6 of Hou, Mol Vis 2010; 16:1659-1668.

Table 6. Pharmacokinetic parameters of retina following mangiferin administration (50 mg/kg, i.v.) by Drug and statistics 2.0

Paremeters Unit Average
t1/2α h 1.87±0.40
t1/2β h 1.87±0.40
V1 L/kg 8.14±1.28
CL L/h/kg 2.52±0.38
AUC(0-t) Mg/L·h-1 15.64±1.98
MRT(0-t) h 1.86±0.07
K12 1/h 0.18±0.19
K21 1/h 0.39±0.09

The concentration-time data after single intravenous administration of 50 mg/kg of mangiferin conformed to a two-compartment model. t1/2(α): distribution half-life; t1/2(β): elimination half-life; V1:Volume of distribution; Cl, clearance;AUC: area under the plasma concentration–time curve; MRT, mean residence time; K12: first order transfer from compartment1 to compartment 2; K21: first order transfer from compartment 2 to compartment 1.

Hou, Mol Vis 2010; 16:1659-1668. http://www.molvis.org/molvis/v16/a179

©2010 Molecular Vision http://www.molvis.org/molvis/

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