Molecular Vision: Hou, Mol Vis 2010; 16:1659-1668. Table 4

Table 4. Pharmacokinetic parameters of plasma following mangiferin administration (10, 25, and 50 mg/kg, i.v.) by Drug and statistics 2.0

Parameters	10 mg/kg	25 mg/kg	50 mg/kg
T_max (h)	0.75±0.27	0.58 ±0.20	0.50±0.01
C_max (μg/ml)	24.75±0.85	56.77±21.13	200.77±32.12
t_1/2α (h)	2.15±0.81	1.60±0.28	0.81±0.60
t_1/2β (h)	3.12±0.04	1.61±0.31	3.25±1.82
AUC_0-t (μg/ml·h⁻¹)	121.48±12.92	205.28±104.30	577.71±63.30
K₂₁ (h⁻¹)	0.09±0.10	0.37±0.19	0.60±0.57
K₁₀ (h⁻¹)	0.18±0.01	0.35±0.05	0.58±0.37
K₁₂ (h⁻¹)	0.17±0.10	0.22±0.25	1.28±1.90
MRT_0-t (h)	5.89±0.06	4.23±0.66	3.10±0.23
CL (L/kg·h⁻¹)	0.06±0.01	0.13±0.06	0.07 ±0.01

The concentration-time data after single intravenous administration of 10, 25 or 50 mg/kg of mangiferin conformed to a two-compartment model. Tmax: time of the maximum plasma concentration; C_max: maximum plasma concentration following drug administration; t_1/2(α): distribution half-life; t_1/2(β): elimination half-life; AUC: area under the plasma concentration–time curve; K₁₀: first order elimination from compartment 1; K₁₂: first order transfer from compartment1 to compartment 2; K₂₁: first order transfer from compartment 2 to compartment 1; MRT, mean residence time. Cl, clearance;