Table 4 of Hou, Mol Vis 2010; 16:1659-1668.


Table 4. Pharmacokinetic parameters of plasma following mangiferin administration (10, 25, and 50 mg/kg, i.v.) by Drug and statistics 2.0

Parameters 10 mg/kg 25 mg/kg 50 mg/kg
Tmax (h) 0.75±0.27 0.58 ±0.20 0.50±0.01
Cmax (μg/ml) 24.75±0.85 56.77±21.13 200.77±32.12
t1/2α (h) 2.15±0.81 1.60±0.28 0.81±0.60
t1/2β (h) 3.12±0.04 1.61±0.31 3.25±1.82
AUC0-t (μg/ml·h−1) 121.48±12.92 205.28±104.30 577.71±63.30
K21 (h−1) 0.09±0.10 0.37±0.19 0.60±0.57
K10 (h−1) 0.18±0.01 0.35±0.05 0.58±0.37
K12 (h−1) 0.17±0.10 0.22±0.25 1.28±1.90
MRT0-t (h) 5.89±0.06 4.23±0.66 3.10±0.23
CL (L/kg·h−1) 0.06±0.01 0.13±0.06 0.07 ±0.01