Figure 6. The immumofluorescence observation (100×) of fibronectin (Fn; green fibers) in rLEC treated with different doses of rapamycin. Panel A shows the control rLECs, while B, C, and D shows treatment of 0.1, 1, and 10 ng/ml rapamycin, repectively, for 24 h exposure. The staining intensities of Fn appeared greater without rapamycin incubation (A). The extracellular matrix is clearly reduced in the rapamycin-treated group. The histogram (E) summarizes the results of scanning densitometry of Fn. All differences were statistically significant, *p≤0.05.