Figure 3. Immediate neighboring residues of Leu113 and the effect of Leu113Ser mutation. The residues shown are, NT-4-Chain A: Y176, W192; NT-4-Chain B: W103' and TrkB: T352 and M354. A: L113 in ball and stick showing the orientation and hydrophobic cluster around Leu113. B: Ser113 in ball and stick showing the gap formed by L113S mutation and the orientation of serine away from hydrophobic cluster.