Figure 1. The mutation in NTF4 identified in the Chinese POAG patient. A: Sequence electropherogram of the NTF4 heterozygous mutation c.338T>C (Leu113Ser) identified in a sporadic POAG case (left). Wild type sequence from an unaffected control individual is shown to the right for comparison. B: Partial sequence (residues 74 to 127) of human (H. sapiens) NT-4 polypeptide compared with orthologs from other mammalian species showing the conservation of the L113 residue as well it’s position in relation to previously reported mutations E84K, A88V and R90H.