Figure 1. Pedigrees of three families affected by Lattice Corneal Dystrophy type 1. A: Pedigree showing six consecutive generations of affected members. B: Pedigree showing two generations with just one affected member in the second generation. C: Pedigree showing two generations with just one affected member in the first generation. Autosomal dominant transmission of the disease is evident in the first family; the other two families are not informative about the transmission pattern since they are too small and include only one affected individual each. Since LCDI has a dominant transmission and the parents are not affected, the pedigree of Family Two suggests a de novo mutation. The arrows at the lower left of the symbol indicate the probands, open and filled symbols indicate unaffected and affected individuals respectively, squares indicate males, and circles indicate females. Asterisks indicate members of the family who underwent clinical examination and molecular analyses.