Table 1 of Pendergrass, Mol Vis 2010; 16:1496-1513. Table 1 of Pendergrass, Mol Vis 2010; 16:1496-1513.
Table 1. Summary of similarities and differences between unirradiated old-mouse lenses and 14-month old mouse lenses X-irradiated at 3 months.
| Type of change | Changes in X-irradiated* mice | Reference |
|---|---|---|
| Surface LEC density | Decreased by 30%–40% | This study [29], |
| Cataract incidence | Increased to grade 3.5 | This study [12,29], |
| Cortical nuclei, debris, DNA | Up over 300% | This study [29] |
| ROS in cortex | Up 4,000% | This study |
| 8-OH-dG staining for ROS damage to DNA | Cortical nuclear fragments positive for 8-OH-dG | This study |
| Alpha smooth muscle actin staining cells | Present only in myofibroblasts on posterior surface by 7–11 months post X-ray. | This study |
| Type of change | Changes seen in unirradiated old mice (at 24–29 months) | Reference |
| Surface LEC density | Down 30%–40% by 24–32 months. | This study [19,20], |
| Cataract incidence | Up ~700% by 24–32 months | [19,20] |
| Internalized nuclei, debris, DNA | Up 350% by 24–32 months | This study [19,20], |
| ROS in cortex | Up −400% by 24–32 months | This study [20] (measured in rat) |
| 8-OH-dG positive cortical nuclei | Cortical nuclear fragments positive by 24–32 months | This study |
| Alpha smooth muscle actin staining for myofibroblasts | None seen | This study |