Figure 7. Drawing of a Müller cell with its nucleus and vimentin cytoskeleton showing the proposed hypothesis of how these cells may undergo nuclear division following retinal injury. Step 1, after retinal detachment the nucleus migrates to the outer nuclear layer (ONL); Step 2, vimentin filaments accumulate around the nucleus after which the nucleus undergoes mitosis; Step 3, one nucleus migrates back to the inner nuclear layer (INL); Step 4, the nucleus remaining in the ONL either moves to the subretinal space and contributes to the formation of a glial scar (Step 5) or remains in the retina as a de-differentiated cell (Step 6).