Table 3 of Shyam, Mol Vis 2010; 16:122-129.

Table 3. Categorization of Wnt components identified in human trabecular meshwork (TM) cells.

Component in Wnt pathway Wnt/β-catenin pathway Wnt/planar cell polarity pathway Wnt/Ca2+ pathway
Wnt ligand Wnt3, Wnt2b Wnt5a, Wnt5b Wnt5a, Wnt5b
Transduction protein Dsh2 Dsh1, Dsh2, Dsh3 Dsh3
Receptor Fzd1, Fzd5, Fzd7, LRP5, LRP6 Fzd2 Fzd4, Fzd2
β-Catenin and Degradation complex CTNNB1, GSK3β, APC NA NA
Transcription factor TCF3, TCF4, TCF7 NA NA
Inhibitor Dkk1, Dkk2, sFRP1, sFRP2, sFRP3 NA NA

Wnt genes that are shown to have roles in all three Wnt signaling, canonical Wnt/β-catenin, and noncanonical Wnt/planar cell polarity and Wnt/Ca2+ pathways were identified in human TM cells. Some of the genes such as Wnt5a, Wnt5b, Dsh2, Dsh3, and Fzd2 have been shown to have functional roles in more than one of the pathways.

Shyam, Mol Vis 2010; 16:122-129. http://www.molvis.org/molvis/v16/a15

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