Molecular Vision: Zhang, Mol Vis 2010; 16:1353-1360. Table 3

Table 3. Protein domain and post-translational modification site predictions for the RP1 wild type protein and the missense variants, p.K1370E and p.R1652L, were analyzed by web-based analysis program ScanProsite.

A. Description	Wild type	p.K1370E
Structural or functional domains	Nil	Nil
Post-translational modification site	Nil	Nil
B. Description	Wild type	p.R1652L
Structural or functional domains	Nil	Nil
Post-translational modification site
Residue 1650–1652	PKC-phospho site (StR)	Nil
Residue 1651–1653	PKC-phospho site (TrK)	PKC-phospho site (TIK)

Difference between wild type and the p.K1370E variant, at position around residue 1370. B. Difference between wild type and the p.R1652L variant, at position around residue 1652. Nil represents None of the protein domain or post-translational modification site was predicted in related location . *PKC-phospho site: Protein kinase C phophosphorylation site. The prediction is based on the amino acid sequence pattern of a serine (S) or threonine (T) residue found close to a C-terminal basic residue such as arginine (R) or Lysine (K) [37,38].