Figure 3. The voltage activation profile examined by tail current analysis in hemichannels from representative cells expressing (A) Cx46 or (B) the combined cRNA derived from the mixture of Cx43 and Cx46 (Cx43•Cx46). The amplitude of the tail current was derived by extrapolating back to the end of the 10 s voltage step. Continuous lines represent curves fit with the Boltzmann equation. Although of similar shape, the curve describing the hemicurrent recorded from oocytes expressing Cx43•46 has a steeper slope, which reflects the difference in gating charge.