Molecular Vision: Zerbib, Mol Vis 2010; 16:1324-1330. Table 5

Table 5. Minor Allele Frequencies and OR of the rs2230199 of the C3 gene in the different studies.

Studies	Number of controls/cases	MAF controls	MAF cases	p	OR (CI95%) CG individuals	OR (CI95%) GG individuals
Yates et al. [22]  English Subjects  Scottish Subjects  Combined Groups	350/603  351/505	0.2  0.2	0.28  0.27	5.9x10⁻⁵ 5.2x10⁻⁴*	1.6 (1.2–2.2)  1.8 (1.2–2.6)  1.7 (1.3–2.1)	2.4 (1.3–4.4)  2.9 (1.4–5.9)  2.6 (1.6–4.1)
Maller et al. [24]	934/1238	0.21	0.31	4.51x10⁻¹²	1.61	3.26
Spencer et al. [23]  Case-controls data set  Family-based data set	286/701  223	0.21	0.29  0.3	0.001*  0.66	1.55 (1.09–2.21) ‡
Bergeron-Sawitzke et al. [25]	215/421				1.9 (1.3–2.7)	2.5 (1.1–5.9)
Francis et al. [28]†  CEIMDC  AREDS	187/211  322/672				0.65 (0.22–1.94)  1.87 (1.38–2.53)	1.93 (1.2–3.1)  3.91 (1.94–7.88)
Despriet et al. [27]  Case-control study  Rotterdam study   Pooled data   Meta-analysis	173/357  4055/476 early AMD  4055/106 late AMD	0.206	0.237earlyAMD  0.254lateAMD		1.27 (1.09–1.49) 1.27 (0.9–1.78)  1.46 (1.11–1.92) 1.93 (1.14–3.28)  1.61 (1.46–1.78)
Park et al. [26] Mayo subjects  AREDS subjects  Pooled data Early AMD  GA  CNV  Late AMD (GA+CNV)	299/439  300/1241				1.4 (1.15–1.69)  1.9 (1.5–2.39)  1.8 (1.47–2.22)  1.8 (1.52–2.21)
Scholl et al. [29] GA	612/99	0.175	0.263	0.0032	1.45 (0.92–2.30)	4.17 (1.67–10.40)
Zerbib et al. [18]	406/1080	0.21	0.26	0.009	1.4 (1.1–1.8) 1.4 (0.8–2.4)  1.4 (1.0–1.9)¨