Figure 2. The concurrent deregulation of the top five canonical pathways in retinoblastoma (RB) tumors. The DNA damage response pathway with breast cancer associated gene 1 (BRCA1) at the center was the top canonical pathway identified with differential gene expression of the RB1 gene. The other pathways were overlaid on this pathway retaining the relationships curated in the knowledge base of Ingenuity software (Redwood, CA).