Table 2 of Strzalka-Mrozik, Mol Vis 2010; 16:1272-1279. Table 2 of Strzalka-Mrozik, Mol Vis 2010; 16:1272-1279.
Table 2. Factors associated with changes in endothelin (ET)-1 gene expression in patients with type 2 diabetus mellitus (DM)
| Variable | n | ET-1 mRNA (copies/mg total RNA)a | p |
|---|---|---|---|
| Gender | |||
| M | 21 | 2620 (267–4383) | NS |
| F | 37 | 3385 (563–5242) | |
| Smoking | |||
| Yes | 6 | 4052 (1382–6035) | NS |
| No | 52 | 2620 (283–4549) | |
| Insulin therapy | |||
| Yes | 31 | 3929 (1710–6278) | 0.003 |
| No | 27 | 1300 (56–3807) | |
| Anti-diabetic drug | |||
| Metformin | |||
| Yes | 36 | 3642 (9674–5242) | NS |
| No | 22 | 1930 (125–3913) | |
| Sulfonyloureas | |||
| Yes | 24 | 1049 (56–3359) | 0.004 |
| No | 34 | 4067 (1464–5912) | |
| Alpha-glucosidase inhibitors | |||
| Yes | 6 | 3215 (2020–4022) | NS |
| No | 52 | 2620 (236–4650) | |
| Anti-hypertensive drug | |||
| β-blocker | |||
| Yes | 13 | 4745 (798–6202) | NS |
| No | 45 | 2575 (259–4341) | |
| Ca-blockers | |||
| Yes | 11 | 2575 (138–5034) | NS |
| No | 47 | 3182 (458–4572) | |
| ACE inhibitor | |||
| Yes | 29 | 1622 (89–4136) | 0.029 |
| No | 29 | 3607 (1244–5109) | |
| Diuretics | |||
| Yes | 12 | 2575 (538–3551) | NS |
| No | 46 | 3521 (275–4682) | |