Table 2 of Strzalka-Mrozik, Mol Vis 2010; 16:1272-1279.


Table 2. Factors associated with changes in endothelin (ET)-1 gene expression in patients with type 2 diabetus mellitus (DM)

Variable n ET-1 mRNA (copies/mg total RNA)a p
Gender
M 21 2620 (267–4383) NS
F 37 3385 (563–5242)
Smoking
Yes 6 4052 (1382–6035) NS
No 52 2620 (283–4549)
Insulin therapy
Yes 31 3929 (1710–6278) 0.003
No 27 1300 (56–3807)
Anti-diabetic drug
Metformin
Yes 36 3642 (9674–5242) NS
No 22 1930 (125–3913)
Sulfonyloureas
Yes 24 1049 (56–3359) 0.004
No 34 4067 (1464–5912)
Alpha-glucosidase inhibitors
Yes 6 3215 (2020–4022) NS
No 52 2620 (236–4650)
Anti-hypertensive drug
β-blocker
Yes 13 4745 (798–6202) NS
No 45 2575 (259–4341)
Ca-blockers
Yes 11 2575 (138–5034) NS
No 47 3182 (458–4572)
ACE inhibitor
Yes 29 1622 (89–4136) 0.029
No 29 3607 (1244–5109)
Diuretics
Yes 12 2575 (538–3551) NS
No 46 3521 (275–4682)