Figure 6. Expression patterns of
transforming growth factor β-receptor type I and type II in an injured
lens epithelium. At day 5 post-injury, multilayered lens epithelial
cells in an injured lens were markedly labeled with anti-TGFβ-RI in a
wild type (WT; A) mouse, while its immunoreactivity was quite
faint in the cells of a tenascin C null (KO; B) mouse. At day
10, the cells of the mutilayer beneath the anterior lens capsule were
labeled for TGFβ-RI in both the WT and KO mice (C, D).
At day 5 post-injury, the multilayered lens epithelial cells in an
injured lens were markedly labeled with anti-TGFβ-RII in a WT mouse (E),
while
its immunoreactivity was quite faint in the cells of a KO mouse (F).
Even
at day 10, immunoreactivity for TGFβ-RII was more prominent in the
WT cells than in the KO cells (G, H); Bar, 10 μm.