Figure 4. Qualitative phenotype comparison of wild type and αA-R49C mutant mouse eyes. Nine-month-old mice were examined using slit-lamp microscopy (above) and histology (below). The images shown are from wild type (A and E), αA-R49C heterozygous mutant (B and F), and αA-R49C homozygous mutant (C, D, and G) mutant mice. Mid-sagittal sections were stained with hematoxylin and eosin. Note the ocular defects in homozygous mutant mice (C, D, and G).