Figure 3. Measurement of lens shape. The
radial dimension of the lens was measured from the intersection of the
optical axis and the equatorial plane as a function of the angle
measured from the anterior pole to the posterior pole for wild type,
6-day-old (black solid line); wild type, 3 months (red solid line);
wild type, 4 months (blue solid line); heterozygous mutant αA-R49C,
6-day-old (black dashed line); heterozygous mutant αA-R49C, 2.5 weeks
(red dashed line); heterozygous mutant αA-R49C, 3 months (blue dashed
line); heterozygous mutant αA-R49C, 4 months (green dashed line);
homozygous mutant αA-R49C, 6-day-old (black dotted line); homozygous
mutant αA-R49C, 2 weeks (red dotted line); homozygous mutant αA-R49C, 4
months (blue dotted line). Note that wild type and αA-R49C heterozygous
mutant lenses were nearly spherical with radial distances increasing
slightly at the equator (angle=90°), whereas homozygous mutant lenses
had a smaller anterior segment and an enlarged posterior segment.