Figure 5. Immunoreactivities of matrix metalloproteinase-2 (MMP-2) and MMP-9. A-D: Immunohistochemical labeling of MMP-2 (A) and MMP-9 (C) in normal control retinas. Retinal photocoagulation resulted in increased MMP-2 (B) and MMP-9 (D) expression in the retinas. Immunoreactivities of cluster differentiation 44 (CD44) and CD44s. E–F: Immunohistochemical labeling of CD44 (E) and CD44s (G) in normal control retinas. Immunohistochemical labeling of CD44 in laser injured retinas (F). Retinal photocoagulation resulted in increased expression of CD44s (H), the degradation product of CD44. Nuclei are counter stained with To-Pro3. Scale bar represents 75 µm.