Figure 3. Serum levels of proinflammatory cytokines are expressed in pg/ml, relative to time interval from CRAO induction. The square-interspersed line indicates the control level in naìve mice. The triangle-interspersed line indicates the control level in rose-bengal-injected mice. Error bars represent SD. The asterisk indicates statistical significance. The specific values are detailed for each cytokine separately. A: MIP-2 Levels were elevated at 1 h. The level at 1 h was statistically significantly higher than levels thereafter (p=0.03). B: IL-6 levels increased at 3 h and remained elevated at 6 h and 12 h. The elevated levels were statistically significantly higher than levels of both control groups (p=0.02, 0.03 and 0.003 for 3 h, 6 h, and 12 h, respectively). C: TNF-α showed an early peak at 1h and late elevation at 1week and 3 weeks. Statistical significance was found only between the early peak and the control levels of rose bengal injected mice.