Figure 3. Effects of NTF2 levels on NTF2 and VEGF mRNA expression. Overexpression of NTF2 by transfection of rAAV2-NTF2 increased the expression level of NTF2 but reduced the expression of VEGF (A, B). Downregulation of NTF2 by transfection with pSIREN-NTF2 siRNA reduced NTF2 expression but increased VEGF expression (C, D). The experiments were performed in rat retinal capillary endothelial cells. Asterisk (*) indicates a significant difference between groups (p<0.05).