Table 1 of Kirwan, Mol Vis 2009; 15:76-88. Table 1 of Kirwan, Mol Vis 2009; 15:76-88.
Table 1. Fifty of the most upregulated and down-regulated probe sets (genes) in POAG LC cells versus normal LC cells.
| PROBE ID | GENE | Mean normal LC array signal (n=2) |
Mean POAG LC array signal (n=2) |
SLR (n=2) |
|---|---|---|---|---|
| 210809_s_at | periostin | 7.7 | 10.7 | 3.0 |
| 212951_at | G protein-coupled receptor 116 | 4.5 | 6.9 | 2.5 |
| 203881_s_at | dystrophin (muscular dystrophy, Duchenne and Becker types) | 5.5 | 7.5 | 2.0 |
| 205523_at | cartilage linking protein 1 | 4.7 | 6.5 | 1.8 |
| 203441_s_at | cadherin 2, type 1, N-cadherin (neuronal) | 6.2 | 7.8 | 1.6 |
| 201150_s_at | tissue inhibitor of metalloproteinase 3 (TIMP-3) | 7.3 | 8.6 | 1.3 |
| 206046_at | a disintegrin and metalloproteinase domain 23 | 5.3 | 6.6 | 1.3 |
| 200974_at | actin, alpha 2, smooth muscle, aorta | 10.2 | 11.5 | 1.2 |
| 212572_at | serine/threonine kinase 38 like | 6.7 | 7.8 | 1.2 |
| 215646_s_at | chondroitin sulfate proteoglycan 2 (versican) | 7.3 | 8.4 | 1.2 |
| 202363_at | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) | 8.0 | 9.1 | 1.1 |
| 202620_s_at | procollagen-lysine, 2-oxoglutarate 5-dioxygenase (lysine hydroxylase) 2 | 6.9 | 8.0 | 1.1 |
| 201310_s_at | chromosome 5 open reading frame 13 | 8.4 | 9.5 | 1.1 |
| 212354_at | sulfatase 1 | 7.5 | 8.6 | 1.1 |
| 201288_at | Rho GDP dissociation inhibitor (GDI) beta | 5.8 | 6.9 | 1.1 |
| 203440_at | cadherin 2, type 1, N-cadherin (neuronal) | 8.0 | 9.0 | 1.0 |
| 211356_x_at | leptin receptor | 5.5 | 6.5 | 1.0 |
| 221011_s_at | likely ortholog of mouse limb-bud and heart gene | 6.8 | 7.7 | 0.9 |
| 210372_s_at | tumor protein D52-like 1 | 7.8 | 8.7 | 0.9 |
| 218717_s_at | myxoid liposarcoma associated protein 4 | 6.8 | 7.6 | 0.8 |
| 213869_x_at | Thy-1 cell surface antigen | 6.7 | 7.5 | 0.8 |
| 217853_at | tensin-like SH2 domain-containing 1 | 6.8 | 7.6 | 0.8 |
| 201110_s_at | thrombospondin 1 | 8.8 | 9.6 | 0.8 |
| 201109_s_at | thrombospondin 1 | 9.8 | 10.5 | 0.8 |
| 205574_x_at | bone morphogenetic protein 1 | 7.2 | 7.9 | 0.7 |
| 203540_at | glial fibrillary acidic protein (GFAP) | 4.0 | 4.0 | 0.0 |
| 212187_x_at | prostaglandin D2 synthase 21 kDa (brain) | 8.9 | 7.2 | −1.7 |
| 213880_at | G protein-coupled receptor 49 | 6.8 | 5.5 | −1.3 |
| 209081_s_at | collagen, type XVIII, alpha 1 | 7.5 | 6.1 | −1.3 |
| 204897_at | prostaglandin E receptor 4 (subtype EP4) | 6.7 | 5.4 | −1.3 |
| 212279_at | hypothetical protein MAC30 | 7.3 | 6.0 | −1.3 |
| 202437_s_at | cytochrome P450, family 1, subfamily B, polypeptide 1 | 8.9 | 7.6 | −1.3 |
| 217997_at | pleckstrin homology-like domain, family A, member 1 | 6.6 | 5.3 | −1.3 |
| 212386_at | transcription factor 4 | 7.5 | 6.4 | −1.1 |
| 209160_at | aldo-keto reductase family 1, member C3 | 6.8 | 5.6 | −1.3 |
| 215034_s_at | transmembrane 4 superfamily member 1 | 8.8 | 7.6 | −1.3 |
| 219064_at | inter-alpha trypsin inhibitor heavy chain precursor 5 | 7.5 | 6.3 | −1.2 |
| 206373_at | Zic family member 1 (odd-paired homolog, Drosophila) | 6.9 | 5.7 | −1.2 |
| 214022_s_at | interferon induced transmembrane protein 1 (9–27) | 7.2 | 6.0 | −1.2 |
| 201525_at | apolipoprotein D | 6.9 | 5.7 | −1.1 |
| 212730_at | desmuslin | 7.2 | 6.1 | −1.1 |
| 204249_s_at | LIM domain only 2 (rhombotin-like 1) | 6.5 | 5.1 | −1.4 |
| 209466_x_at | pleiotrophin | 8.0 | 6.9 | −1.1 |
| 202434_s_at | cytochrome P450, family 1, subfamily B, polypeptide 1 | 6.7 | 5.6 | −1.0 |
| 213891_s_at | transcription factor 4 | 7.2 | 6.2 | −1.0 |
| 218625_at | neuritin 1 | 7.1 | 6.2 | −1.0 |
| 208791_at | clusterin | 8.0 | 7.1 | −0.9 |
| 202075_s_at | phospholipid transfer protein | 6.9 | 6.0 | −0.9 |
| 209335_at | decorin | 7.7 | 6.9 | −0.9 |
| 204987_at | inter-alpha (globulin) inhibitor, H2 polypeptide | 6.2 | 5.4 | −0.9 |
| 212992_at | chromosome 14 open reading frame 78 | 7.9 | 7.2 | −0.8 |