Figure 7. Lens rupture in AND-34^−/− mice occurs postnatally following initial development of lens vacuolization. AND-34^−/− eyes from 3-, 24-, and 33-day-old AND-34^−/− mice (P3, P24, and P33) were fixed, plastic embedded, and sectioned. Vacuolization of the cortical lens fibers but no examples of lens rupture were identified in the eyes of three-day-old mice (upper panels). Lens rupture with extrusion of cortical fiber material was first detected in 24- and 33-day old mice (lower panels).