Figure 4. Ocular phenotype in AND-34^−/− mice. A: The lens cortex was observed in the anterior chamber of the eye in a subset of AND-34^−/− mice (four-month-old mouse shown on right). Comparable abnormalities were never observed in AND-34^-/+ or AND-34^+/+ mouse eyes (left). B: Dissected whole lens from a three-month-old AND-34^−/− 129 strain mouse was compared with a three-month-old AND-34^+/+ lens as viewed under a dissecting microscope. The AND-34^+/+ lens was a uniform translucent, smooth, spherical structure whereas the lens from the AND-34^−/− mouse eye was a partially opaque, irregular structure that had clearly lost a portion of its internal contents.