Figure 6. Evolution of the CNV reaction with aging. A: This reaction reaches its peak during the first two weeks after photocoagulation (PC), diminishes progressively after, and is still present on month 4. Choroidal neovascularization is rare and difficult to quantify in 4-week-old mice (group I). It is more prominent in 10–12-week-old mice and 1-year-old mice. It diminishes more markedly in young adult mice after two months. On month 4, the difference is statistically significant between young adult and old mice. A p<0.0001 was considered significant. B: The mean CNV area during the first two weeks after PC is significantly larger in old mice in comparison to young adult mice according to t-test.