Table 3 of Sharma, Mol Vis 2009; 15:60-69. Table 3 of Sharma, Mol Vis 2009; 15:60-69.
Table 3. List of 10 most statistically significant canonical pathways maps represented by detectable analytes in normal aqueous samples.
| Number | Key network objects | GO Processes | p value | zScore | gScore |
|---|---|---|---|---|---|
| 1 | A2M, Kallikrein 3 (PSA), Alpha 1-antitrypsin, VEGF-A, PAI1 | organ development (61.4%; 4.075e−10), response to wounding (36.4%; 4.455e−10), response to external stimulus (43.2%; 4.572e−10), cell proliferation (50.0%; 5.309e−10), positive regulation of cell proliferation (31.8%; 6.986e−10) | 2.36e−31 | 61.1 | 61.1 |
| 2 | Stromelysin-1, CCL2, TIMP1, MIP-1-beta, Alpha 1-antitrypsin | response to external stimulus (47.8%; 1.468e−12), response to wounding (37.0%; 9.322e−11), wound healing (23.9%; 1.290e−10), blood coagulation (15.2%; 3.146e−07), coagulation (15.2%; 3.914e−07) | 8.46e−29 | 57.4 | 57.4 |
| 3 | VEGF-A, Endothelin-1, PAI1, Stromelysin-1, CD40(TNFRSF5) | response to stimulus (75.5%; 5.440e−14), response to stress (55.1%; 3.472e−13), protein kinase cascade (40.8%; 3.739e−13), response to external stimulus (46.9%; 7.466e−13), cell surface receptor linked signal transduction (57.1%; 1.494e−12) | 1.14e−28 | 56.8 | 56.8 |
| 4 | F3, Beta-2-glycoprotein I (APOH), VCAM1, MIP-1-beta, CCL2 | cell adhesion (53.2%; 8.293e−19), biological adhesion (53.2%; 8.293e−19), response to wounding (51.1%; 1.218e−18), localization of cell (51.1%; 5.939e−17), cell motility (51.1%; 5.939e−17) | 1.14e−28 | 56.8 | 58.1 |
| 5 | CD40(TNFRSF5), CRP, G-CSF, F3, APCS | immune system process (57.1%; 2.349e−16), immune response (44.9%; 1.384e−14), response to stimulus (73.5%; 4.961e−13), defense response (40.8%; 6.493e−12), adaptive immune response (20.4%; 1.681e−10) | 1.14e−28 | 56.8 | 56.8 |
| 6 | APOA1, PPAP, Adiponectin, APOC3, MIP-1-alpha | sterol transport (15.2%; 3.842e−08), cholesterol transport (15.2%; 3.842e−08), triacylglycerol metabolic process (12.1%; 1.119e−06), lipid transport (15.2%; 1.661e−06), response to stimulus (63.6%; 1.781e−06) | 4.46e−27 | 57.2 | 57.2 |
| 7 | CCL2, CCL5, Eotaxin, MIP-1-beta, MIP-1-alpha | cytokine and chemokine mediated signaling pathway (25.5%; 4.692e−17), locomotory behavior (38.3%; 1.594e−16), chemotaxis (31.9%; 5.793e−16), taxis (31.9%; 5.793e−16), response to external stimulus (53.2%; 1.704e−15) | 1.82e−23 | 48 | 68 |
| 8 | A2M, Endothelin-1, CCL5, IL-6, MIP-1-beta | response to stimulus (75.5%; 5.440e−14), response to external stimulus (49.0%; 7.073e−14), regulation of protein metabolic process (34.7%; 5.809e−13), defense response (42.9%; 6.006e−13), inflammatory response (34.7%; 1.171e−12) | 5.95e−21 | 43.6 | 43.6 |
| 9 | Beta-2-microglobulin, APOA1, TR2(TNFRSF14), VCAM1, GSTM1 | response to stimulus (75.0%; 1.873e−11), positive regulation of transferase activity (27.5%; 2.304e−10), positive regulation of kinase activity (25.0%; 3.531e−09), positive regulation of catalytic activity (27.5%; 2.827e−08), regulation of transferase activity (27.5%; 3.249e−08) | 4.09e−16 | 34.9 | 34.9 |
| 10 | PPAP, Thyroxine-binding globulin, Adiponectin, Epo, APOLPA | protein kinase cascade (34.3%; 2.065e−07), intracellular signaling cascade (48.6%; 2.204e−07), positive regulation of kinase activity (22.9%; 2.930e−07), positive regulation of transferase activity (22.9%; 3.458e−07), regulation of cell differentiation (25.7%; 3.570e−07) | 2.29e−14 | 33.3 | 33.3 |